PMID- 28400924 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1949-8462 (Print) IS - 1949-8462 (Electronic) VI - 9 IP - 3 DP - 2017 Mar 26 TI - Risk of ventricular arrhythmia in patients with myocardial infarction and non-obstructive coronary arteries and normal ejection fraction. PG - 268-276 LID - 10.4330/wjc.v9.i3.268 [doi] AB - AIM: To assess the arrhythmic determinants and prognosis of patients presenting with myocardial infarction and non-obstructive coronary arteries (MINOCA) with normal ejection fraction (EF). METHODS: This is an observational analysis of 131 MINOCA patients with normal EF. Three cardiac magnetic resonance (CMR) diagnosis classes were recognized according to the late gadolinium enhancement (LGE) pattern: Myocardial infarction (MI) (n = 34), myocarditis (n = 47), and "no LGE" (n = 50). Ventricular events occurring during hospitalization were recorded and the entire population was followed-up at 1 year. RESULTS: Ventricular arrhythmia was observed in 18 (13.8%) patients during hospitalization. The "no LGE" patients experienced fewer ventricular events than the MI and myocarditis patients [4.0% vs 26.5% and 14.9%, respectively (P = 0.013)]. There was no significant difference between the MI and myocarditis groups. On multivariate analysis, LGE transmural extent [OR = 1.52 (1.08-2.15), P = 0.017] and ST-segment elevation [OR = 4.65 (1.61-13.40), P = 0.004] were independent predictors of ventricular arrhythmic events, irrespective of the diagnosis class. Finally, no patient experienced sudden cardiac death or ventricular arrhythmia recurrence at 1-year. CONCLUSION: MINOCA patients with normal EF presented no 1-year cardiovascular events, irrespective of the CMR diagnosis class. LGE transmural extent and ST segment elevation at admission are risk markers of ventricular arrhythmia during hospitalization. FAU - Biere, Loic AU - Biere L AD - Loic Biere, Marjorie Niro, Fabrice Prunier, Alain Furber, Laboratoire Cardioprotection, Institut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, F-49045 Angers, France. FAU - Niro, Marjorie AU - Niro M AD - Loic Biere, Marjorie Niro, Fabrice Prunier, Alain Furber, Laboratoire Cardioprotection, Institut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, F-49045 Angers, France. FAU - Pouliquen, Herve AU - Pouliquen H AD - Loic Biere, Marjorie Niro, Fabrice Prunier, Alain Furber, Laboratoire Cardioprotection, Institut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, F-49045 Angers, France. FAU - Gourraud, Jean-Baptiste AU - Gourraud JB AD - Loic Biere, Marjorie Niro, Fabrice Prunier, Alain Furber, Laboratoire Cardioprotection, Institut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, F-49045 Angers, France. FAU - Prunier, Fabrice AU - Prunier F AD - Loic Biere, Marjorie Niro, Fabrice Prunier, Alain Furber, Laboratoire Cardioprotection, Institut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, F-49045 Angers, France. FAU - Furber, Alain AU - Furber A AD - Loic Biere, Marjorie Niro, Fabrice Prunier, Alain Furber, Laboratoire Cardioprotection, Institut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, F-49045 Angers, France. FAU - Probst, Vincent AU - Probst V AD - Loic Biere, Marjorie Niro, Fabrice Prunier, Alain Furber, Laboratoire Cardioprotection, Institut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, F-49045 Angers, France. LA - eng PT - Journal Article PL - United States TA - World J Cardiol JT - World journal of cardiology JID - 101537090 PMC - PMC5368677 OTO - NOTNLM OT - Cardiac magnetic resonance OT - Late gadolinium enhancement OT - Myocardial infarction OT - Myocardial infarction and non-obstructive coronary arteries OT - Myocarditis OT - Ventricular tachycardia COIS- Conflict-of-interest statement: The authors have no conflict of interest to disclose. EDAT- 2017/04/13 06:00 MHDA- 2017/04/13 06:01 PMCR- 2017/03/26 CRDT- 2017/04/13 06:00 PHST- 2016/07/13 00:00 [received] PHST- 2016/11/04 00:00 [revised] PHST- 2016/12/16 00:00 [accepted] PHST- 2017/04/13 06:00 [entrez] PHST- 2017/04/13 06:00 [pubmed] PHST- 2017/04/13 06:01 [medline] PHST- 2017/03/26 00:00 [pmc-release] AID - 10.4330/wjc.v9.i3.268 [doi] PST - ppublish SO - World J Cardiol. 2017 Mar 26;9(3):268-276. doi: 10.4330/wjc.v9.i3.268.