PMID- 28401023
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 7
IP  - 3
DP  - 2017
TI  - Biopolymer based nanosystem for doxorubicin targeted delivery.
PG  - 715-726
AB  - This study describes formation of an actively and passively targeted, 
      water-soluble drug delivery system (DDS) which contains doxorubicin (DOX). The 
      system comprises two biocompatible and biodegradable polymers: poly-gamma-glutamic 
      acid (PGA) and chitosan (CH). Self-assembly of these biopolymers in aqueous 
      medium results stable nanoparticles (NPs) with a hydrodynamic size of 80-150 nm 
      and slightly negative surface charge. Folic acid (FA) was used as targeting agent 
      bonded to the polyanion (PA) and also to the surface of the NPs. The NP's 
      physical stability, active targeting effect, cellular toxicity, release profile 
      and in vivo anti-tumor efficacy were investigated. It was found that the 
      targeted, self-assembled nanoparticles are stable at 4 degrees C for several months, 
      cause better in vitro toxicity effect on folate receptor (FR) positive cell lines 
      than the doxorubicin or the non-targeted nanosystem and based on its release 
      profile it is expected, that the nanosystem will remain stable during the 
      circulation in the body. Pharmacodynamic studies demonstrated that the DOX-loaded 
      nanoparticles can deliver greater tumor growth inhibition than the free drug 
      molecules and the liposomal compound, with less general toxicity. It was observed 
      that the overall survival is the main benefit of the biopolymer based drug 
      delivery system.
FAU - Csikos, Zsuzsanna
AU  - Csikos Z
AD  - BBS Nanotechnology Ltd. Boszormenyi 212., H-4032 Debrecen, Hungary.
FAU - Kerekes, Krisztina
AU  - Kerekes K
AD  - BBS Nanotechnology Ltd. Boszormenyi 212., H-4032 Debrecen, Hungary.
FAU - Fazekas, Erika
AU  - Fazekas E
AD  - BBS Nanotechnology Ltd. Boszormenyi 212., H-4032 Debrecen, Hungary.
FAU - Kun, Sandor
AU  - Kun S
AD  - BBS Nanotechnology Ltd. Boszormenyi 212., H-4032 Debrecen, Hungary.
FAU - Borbely, Janos
AU  - Borbely J
AD  - BBS Nanotechnology Ltd.Boszormenyi 212., H-4032 Debrecen, Hungary; Department of 
      Radiology, Faculty of Medicine, University of DebrecenNagyerdei krt. 94., H-4032 
      Debrecen, Hungary.
LA  - eng
PT  - Journal Article
DEP - 20170301
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC5385654
OTO - NOTNLM
OT  - Biopolymers
OT  - doxorubicin
OT  - drug delivery
OT  - folate-targeted
OT  - in vitro release
OT  - in vivo anti-tumor efficacy
OT  - self-assembled nanoparticles
EDAT- 2017/04/13 06:00
MHDA- 2017/04/13 06:01
PMCR- 2017/03/01
CRDT- 2017/04/13 06:00
PHST- 2016/12/18 00:00 [received]
PHST- 2017/01/12 00:00 [accepted]
PHST- 2017/04/13 06:00 [entrez]
PHST- 2017/04/13 06:00 [pubmed]
PHST- 2017/04/13 06:01 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2017 Mar 1;7(3):715-726. eCollection 2017.