PMID- 28401151
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - White Matter Integrity in Genetic High-Risk Individuals and First-Episode 
      Schizophrenia Patients: Similarities and Disassociations.
PG  - 3107845
LID - 10.1155/2017/3107845 [doi]
LID - 3107845
AB  - White matter (WM) neuroimaging studies have shown varied findings at different 
      stages of schizophrenia (SZ). Understanding these variations may elucidate 
      distinct markers of genetic vulnerability and conversion to psychosis. To examine 
      the similarities and differences in WM connectivity between those at-risk for and 
      in early stages of SZ, a cross-sectional diffusion tensor imaging study of 48 
      individuals diagnosed with first-episode SZ (FE-SZ), 37 nonpsychotic individuals 
      at a high genetic risk of SZ (GHR-SZ), and 67 healthy controls (HC) was 
      conducted. Decreased fractional anisotropy (FA) in the corpus callosum (CC), 
      anterior cingulum (AC), and uncinate fasciculus (UF) was observed in both the 
      GHR-SZ and FE-SZ groups, while decreased FAs in the superior longitudinal 
      fasciculus (SLF) and the fornix were only seen in the FE-SZ participants. 
      Additionally, both GHR-SZ and FE-SZ showed worse executive performance than HC. 
      The left SLF III FA was significantly positively correlated with hallucinations, 
      and right SLF II was positively correlated with thought disorder. The presence of 
      shared WM deficits in both FE-SZ and GHR-SZ individuals may reflect the genetic 
      liability to SZ, while the disparate FA changes in the FE-SZ group may represent 
      symptom-generating circuitry that mediates perceptual and cognitive disturbances 
      of SZ and ultimately culminates in the onset of psychotic episodes.
FAU - Zhou, Yifang
AU  - Zhou Y
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China; Department of Geriatrics, The First 
      Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
FAU - Driesen, Naomi
AU  - Driesen N
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
FAU - Womer, Fay
AU  - Womer F
AD  - Department of Psychiatry, Washington University School of Medicine, St. Louis, 
      MO, USA.
FAU - Chen, Kaiyuan
AU  - Chen K
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China.
FAU - Wang, Ye
AU  - Wang Y
AD  - Mental Health Center of Shenyang, Shenyang, Liaoning, China.
FAU - Jiang, Xiaowei
AU  - Jiang X
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China.
FAU - Zhou, Qian
AU  - Zhou Q
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China.
FAU - Bai, Chuan
AU  - Bai C
AD  - Department of Radiology, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China.
FAU - Wang, Dahai
AU  - Wang D
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China.
FAU - Tang, Yanqing
AU  - Tang Y
AUID- ORCID: 0000-0003-1099-905X
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China; Department of Geriatrics, The First 
      Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
FAU - Wang, Fei
AU  - Wang F
AUID- ORCID: 0000-0002-5764-9957
AD  - Department of Psychiatry, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning, China; Department of Radiology, The First 
      Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
LA  - eng
PT  - Journal Article
DEP - 20170319
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Adult
MH  - Corpus Callosum/diagnostic imaging/physiopathology
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Hallucinations/diagnostic imaging/physiopathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Neuroimaging/*methods
MH  - Psychotic Disorders/*diagnostic imaging/physiopathology
MH  - Schizophrenia/*diagnostic imaging/physiopathology
MH  - White Matter/*diagnostic imaging/physiopathology
PMC - PMC5376415
COIS- The authors declare no conflict of interests.
EDAT- 2017/04/13 06:00
MHDA- 2017/04/30 06:00
PMCR- 2017/03/19
CRDT- 2017/04/13 06:00
PHST- 2016/05/21 00:00 [received]
PHST- 2017/02/16 00:00 [accepted]
PHST- 2017/04/13 06:00 [entrez]
PHST- 2017/04/13 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
PHST- 2017/03/19 00:00 [pmc-release]
AID - 10.1155/2017/3107845 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:3107845. doi: 10.1155/2017/3107845. Epub 2017 Mar 19.