PMID- 28401683
OWN - NLM
STAT- MEDLINE
DCOM- 20180221
LR  - 20181202
IS  - 1462-2920 (Electronic)
IS  - 1462-2912 (Linking)
VI  - 19
IP  - 10
DP  - 2017 Oct
TI  - A global survey of bacterial type III secretion systems and their effectors.
PG  - 3879-3895
LID - 10.1111/1462-2920.13755 [doi]
AB  - The type III secretion system (T3SS) is an important genetic determinant that 
      mediates interactions between Gram-negative bacteria and their eukaryotic hosts. 
      Our understanding of the T3SS continues to expand, yet the availability of new 
      bacterial genomes prompts questions about its diversity, distribution and 
      evolution. Through a comprehensive survey of  approximately 20 000 bacterial genomes, we 
      identified 174 non-redundant T3SSs from 109 genera and 5 phyla. Many of the 
      bacteria are environmental strains that have not been reported to interact with 
      eukaryotic hosts, while several species groups carry multiple T3SSs. Four 
      ultra-conserved Microsynteny Blocks (MSBs) were defined within the T3SSs, 
      facilitating comprehensive clustering of the T3SSs into 13 major categories, and 
      establishing the largest diversity of T3SSs to date. We subsequently extended our 
      search to identify type III effectors, resulting in 8740 candidate effectors. 
      Lastly, an analysis of the key transcriptional regulators and circuits for the 
      T3SS families revealed that low-level T3SS regulators were more conserved than 
      higher-level regulators. This comprehensive analysis of the T3SSs and their 
      protein effectors provides new insight into the diversity of systems used to 
      facilitate host-bacterial interactions.
CI  - (c) 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.
FAU - Hu, Yueming
AU  - Hu Y
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, 
      Shenzhen University Health Science Center, Shenzhen, 518060, P.R. China.
FAU - Huang, He
AU  - Huang H
AD  - MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen 
      Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      Beijing, China.
FAU - Cheng, Xi
AU  - Cheng X
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, 
      Shenzhen University Health Science Center, Shenzhen, 518060, P.R. China.
FAU - Shu, Xingsheng
AU  - Shu X
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, 
      Shenzhen University Health Science Center, Shenzhen, 518060, P.R. China.
FAU - White, Aaron P
AU  - White AP
AD  - Vaccine and Infectious Disease Organization, University of Saskatchewan, 
      Saskatoon, SK, Canada.
FAU - Stavrinides, John
AU  - Stavrinides J
AD  - Department of Biology, University of Regina, Regina, SK, Canada.
FAU - Koster, Wolfgang
AU  - Koster W
AD  - Vaccine and Infectious Disease Organization, University of Saskatchewan, 
      Saskatoon, SK, Canada.
FAU - Zhu, Guoqiang
AU  - Zhu G
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
FAU - Zhao, Zhendong
AU  - Zhao Z
AD  - MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen 
      Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      Beijing, China.
FAU - Wang, Yejun
AU  - Wang Y
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, 
      Shenzhen University Health Science Center, Shenzhen, 518060, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170510
PL  - England
TA  - Environ Microbiol
JT  - Environmental microbiology
JID - 100883692
RN  - 0 (Bacterial Proteins)
RN  - 0 (Type III Secretion Systems)
SB  - IM
MH  - Bacterial Proteins/genetics/metabolism
MH  - Genome, Bacterial/genetics
MH  - Gram-Negative Bacteria/genetics/*metabolism
MH  - Host-Pathogen Interactions/physiology
MH  - Proteobacteria/genetics/*metabolism
MH  - Type III Secretion Systems/genetics/*metabolism
EDAT- 2017/04/13 06:00
MHDA- 2018/02/22 06:00
CRDT- 2017/04/13 06:00
PHST- 2016/08/24 00:00 [received]
PHST- 2017/04/04 00:00 [accepted]
PHST- 2017/04/13 06:00 [pubmed]
PHST- 2018/02/22 06:00 [medline]
PHST- 2017/04/13 06:00 [entrez]
AID - 10.1111/1462-2920.13755 [doi]
PST - ppublish
SO  - Environ Microbiol. 2017 Oct;19(10):3879-3895. doi: 10.1111/1462-2920.13755. Epub 
      2017 May 10.