PMID- 28401744
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20171003
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 59
IP  - 4
DP  - 2017 Apr
TI  - FDG-PET in macrophage activation syndrome associated with systemic juvenile 
      idiopathic arthritis.
PG  - 509-511
LID - 10.1111/ped.13238 [doi]
AB  - We herein describe a case of systemic juvenile idiopathic arthritis 
      (s-JIA)-associated macrophage activation syndrome (MAS) in which the (18F) 
      fluorodeoxyglucose positron emission tomography ((18)(F) FDG-PET) findings were 
      characteristic. The pattern of greater (18)(F) FDG accumulation into the spleen 
      compared with the liver was more remarkable in this patient compared with s-JIA. 
      This pattern, however, was also observed in cases of acute leukemia. In the 
      present patient, serum interleukin (IL)-18 was extremely elevated 
      (255 000 pg/mL), whereas in leukemia patients it is mildly elevated 
      (360-1480 pg/mL). (18)(F) FDG-PET might be a useful indicator of s-JIA and MAS in 
      patients with fever of unknown origin. The pattern of (18)(F) FDG accumulation, 
      however, can also be observed in acute leukemia. The combination of (18)(F) 
      FDG-PET and serum IL-18 might be useful for the diagnosis of s-JIA and MAS.
CI  - (c) 2017 Japan Pediatric Society.
FAU - Shimizu, Masaki
AU  - Shimizu M
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Ikawa, Yasuhiro
AU  - Ikawa Y
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Mizuta, Mao
AU  - Mizuta M
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Takakura, Maiko
AU  - Takakura M
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Inoue, Natsumi
AU  - Inoue N
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Nishimura, Ryosei
AU  - Nishimura R
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Yachie, Akihiro
AU  - Yachie A
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Arthritis, Juvenile/complications/*diagnostic imaging
MH  - Child, Preschool
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Macrophage Activation Syndrome/*diagnostic imaging/etiology
MH  - Positron-Emission Tomography/*methods
MH  - *Radiopharmaceuticals
OTO - NOTNLM
OT  - fluorodeoxyglucose positron emission tomography
OT  - interleukin-18
OT  - macrophage activation syndrome
OT  - systemic juvenile idiopathic arthritis
EDAT- 2017/04/13 06:00
MHDA- 2017/10/04 06:00
CRDT- 2017/04/13 06:00
PHST- 2016/11/02 00:00 [received]
PHST- 2016/12/13 00:00 [revised]
PHST- 2017/01/11 00:00 [accepted]
PHST- 2017/04/13 06:00 [entrez]
PHST- 2017/04/13 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
AID - 10.1111/ped.13238 [doi]
PST - ppublish
SO  - Pediatr Int. 2017 Apr;59(4):509-511. doi: 10.1111/ped.13238.