PMID- 28401896
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20181113
IS  - 1559-064X (Electronic)
IS  - 1559-0631 (Linking)
VI  - 27
IP  - 5
DP  - 2017 Sep
TI  - Lead exposure, IgE, and the risk of asthma in children.
PG  - 478-483
LID - 10.1038/jes.2017.5 [doi]
AB  - Lead (Pb) has adverse effects on our nervous system and renal systems. Young 
      children are more vulnerable to Pb exposure. However, the role of low-level Pb 
      exposure in the immune system and allergic diseases in children is not well 
      established. The aims of this study are to investigate the associations between 
      Pb exposure and allergic diseases; between Pb and immunoglobulin E (IgE) as an 
      intervening variable; and gender-based differences. We used multistage stratified 
      random sampling to recruit kindergarten children nationwide in Taiwan. 
      Information about allergic diseases and environmental exposures was collected by 
      questionnaire. We compared children with and without allergic diseases for blood 
      Pb levels measured by inductively coupled plasma mass spectrometry. The 
      association between blood Pb and allergic diseases was assessed by logistic 
      regression and those between Pb and IgE by generalized linear models. We also 
      conducted mediation analysis to evaluate how much risk of allergic diseases 
      related to Pb exposure is explained by IgE. A total of 930 children completed 
      specimen collections. There was a positive association between Pb and asthma. 
      Blood Pb were also positively linked with serum IgE (beta=0.26 kU/l per ln-unit 
      increase Pb concentration; 95% CI 0.009-0.50 kU/l), after adjusting for potential 
      confounders. Analyses stratified by gender revealed that blood Pb correlated with 
      IgE only in boys (beta=0.40 kU/l; 95% CI 0.03-0.76 kU/l). We estimated that 38% of 
      the total effect of Pb exposure on asthma is mediated by IgE levels. In 
      conclusion, Pb exposure is associated with both blood IgE and asthma in boys. 
      Moreover, the effect of Pb exposure on asthma may be mediated by IgE levels.
FAU - Wang, I-Jen
AU  - Wang IJ
AD  - Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, 
      Taipei, Taiwan.
AD  - Institute of Environmental and Occupational Health Sciences, School of Medicine, 
      National Yang-Ming University, Taipei, Taiwan.
AD  - Department of Health Risk Management, China Medical University, Taichung, Taiwan.
FAU - Karmaus, Wilfried J J
AU  - Karmaus WJJ
AD  - Division of Epidemiology, Biostatistics, and Environmental Health, School of 
      Public Health, University of Memphis, Memphis, Tennessee, USA.
FAU - Yang, Chen-Chang
AU  - Yang CC
AD  - Institute of Environmental and Occupational Health Sciences, School of Medicine, 
      National Yang-Ming University, Taipei, Taiwan.
AD  - Division of Clinical Toxicology &Occupational Medicine, Department of Medicine, 
      Taipei Veterans General Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170412
PL  - United States
TA  - J Expo Sci Environ Epidemiol
JT  - Journal of exposure science & environmental epidemiology
JID - 101262796
RN  - 2P299V784P (Lead)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/*epidemiology
MH  - Child
MH  - Child, Preschool
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Lead/blood/*toxicity
MH  - Male
MH  - Mass Spectrometry
MH  - Risk Factors
MH  - Taiwan/epidemiology
EDAT- 2017/04/13 06:00
MHDA- 2018/05/09 06:00
CRDT- 2017/04/13 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/04/13 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
PHST- 2017/04/13 06:00 [entrez]
AID - jes20175 [pii]
AID - 10.1038/jes.2017.5 [doi]
PST - ppublish
SO  - J Expo Sci Environ Epidemiol. 2017 Sep;27(5):478-483. doi: 10.1038/jes.2017.5. 
      Epub 2017 Apr 12.