PMID- 28403087
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 15
DP  - 2017 Apr
TI  - Increased BDNF may not be associated with cognitive impairment in 
      heroin-dependent patients.
PG  - e6582
LID - 10.1097/MD.0000000000006582 [doi]
LID - e6582
AB  - A growing number of evidence suggests that brain-derived neurotrophic factor 
      (BDNF) plays an important part in modulating the activities on the basis of 
      hippocampus neural plasticity, such as learning and memory. Heroin addiction has 
      a series of cognitive impairments that may be associated with BDNF. In this 
      study, we explored the association of BDNF with cognitive function in 
      heroin-dependent patients.We enrolled 86 heroin-dependent patients and 238 normal 
      control subjects and examined their cognition by the repeatable battery for the 
      assessment of neuropsychological status (RBANS) and serum BDNF levels in 2 
      groups.BDNF levels were significantly higher in patients than controls 
      (P < .001). Cognitive scores of the RBANS showed that attention and language 
      index (P < .05) were significantly lower in heroin-dependent patients than 
      control groups. Unfortunately, we found no positive association between BDNF and 
      cognitive function in patients, except that BDNF was positively associated with 
      visuospatial/constructional index in control groups.Our findings suggest that 
      BDNF may not be involved in the pathophysiology of heroin dependence, but more 
      studies about cognitive impairment in heroin addiction are needed.
FAU - Luan, Xiaoqian
AU  - Luan X
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou Department of Rehabilitation Medicine, Sir Run Run Shaw 
      Hospital, College of Medicine, Zhejiang University, Hangzhou Shanghai Mental 
      Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Beijing 
      HuiLongGuan Hospital, Peking University, Beijing, PR China Menninger Department 
      of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, 
      USA.
FAU - Tao, Jingyan
AU  - Tao J
FAU - Zhang, Jie
AU  - Zhang J
FAU - Xie, Ying
AU  - Xie Y
FAU - Zhang, Xiangyang
AU  - Zhang X
FAU - Su, Hang
AU  - Su H
FAU - He, Jincai
AU  - He J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Attention/drug effects
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cognition/drug effects
MH  - Cognitive Dysfunction/blood/*chemically induced
MH  - Female
MH  - Heroin Dependence/*blood/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC5403084
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2017/04/14 06:00
MHDA- 2017/04/30 06:00
PMCR- 2017/04/14
CRDT- 2017/04/14 06:00
PHST- 2017/04/14 06:00 [entrez]
PHST- 2017/04/14 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
PHST- 2017/04/14 00:00 [pmc-release]
AID - 00005792-201704140-00020 [pii]
AID - MD-D-16-06703 [pii]
AID - 10.1097/MD.0000000000006582 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Apr;96(15):e6582. doi: 10.1097/MD.0000000000006582.