PMID- 28403684
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20180417
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 39
IP  - 8
DP  - 2017 Aug
TI  - Mangiferin prevents corticosterone-induced behavioural deficits via alleviation 
      of oxido-nitrosative stress and down-regulation of indoleamine 2,3-dioxygenase 
      (IDO) activity.
PG  - 709-718
LID - 10.1080/01616412.2017.1310705 [doi]
AB  - BACKGROUND: In recent years, a substantial amount of experimental studies have 
      demonstrated that exogenous administration of corticosterone causes anxiety and 
      depressive-like behaviour in rodents which involves 
      hypothalamic-pituitary-adrenal axis dysregulation. Our present study aimed to 
      explore the neuroprotective potential of mangiferin against 
      corticosterone-induced anxiety and depressive-like behaviour. METHODS: 
      Corticosterone (40 mg/kg; subcutaneously) was administered once daily in swiss 
      albino mice for 21 days. Mice were treated simultaneously with mangiferin 
      (40 mg/kg; p.o.), 30 min prior to the corticosterone injection. RESULTS: Chronic 
      administration of corticosterone caused anxiety and depressive-like behaviour in 
      mice which was significantly alleviated by mangiferin treatment. Biochemical 
      analysis revealed that mangiferin treatment significantly attenuated 
      corticosterone-induced oxido-nitrosative stress and neuroinflammation in the 
      hippocampus region. Furthermore, concomitant treatment with mangiferin 
      significantly enhanced the hippocampal brain-derived neurotrophic factor (BDNF) 
      level and decreased the serum corticosterone level in the corticosterone-treated 
      animals. Western blotting analysis revealed that corticosterone administration 
      significantly up-regulated the indoleamine 2,3-dioxygenase (IDO) protein 
      expression level in the hippocampus which was significantly reduced by mangiferin 
      treatment. CONCLUSION: Taken together, our results suggest that mangiferin exerts 
      anti-anxiety and antidepressant effect in corticosterone-treated rats, which is 
      probably mediated through up-regulation of BDNF level along with inhibition of 
      oxido-nitrosative stress, neuroinflammation and IDO up-regulation in the 
      hippocampus region.
FAU - Luo, Gao-Quan
AU  - Luo GQ
AD  - a Department of Neurology , Guangzhou General Hospital of Guangzhou Military 
      Command , Guangdong , China.
FAU - Liu, Ling
AU  - Liu L
AD  - b Department of The Geriatric Ward , Guangzhou General Hospital of Guangzhou 
      Military Command , Guangdong , China.
FAU - Gao, Qu-Wen
AU  - Gao QW
AD  - a Department of Neurology , Guangzhou General Hospital of Guangzhou Military 
      Command , Guangdong , China.
FAU - Wu, Xiao-Na
AU  - Wu XN
AD  - a Department of Neurology , Guangzhou General Hospital of Guangzhou Military 
      Command , Guangdong , China.
FAU - Xiang, Wei
AU  - Xiang W
AD  - a Department of Neurology , Guangzhou General Hospital of Guangzhou Military 
      Command , Guangdong , China.
FAU - Deng, Wen-Ting
AU  - Deng WT
AD  - a Department of Neurology , Guangzhou General Hospital of Guangzhou Military 
      Command , Guangdong , China.
LA  - eng
PT  - Journal Article
DEP - 20170412
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Xanthones)
RN  - 1M84LD0UMD (mangiferin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/toxicity
MH  - Anxiety/chemically induced
MH  - Behavior, Animal/drug effects
MH  - Corticosterone/toxicity
MH  - Depression/chemically induced
MH  - Down-Regulation
MH  - Hippocampus/*drug effects
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/*metabolism
MH  - Male
MH  - Mice
MH  - Nitrosative Stress/*drug effects
MH  - Oxidative Stress/*drug effects
MH  - Xanthones/*pharmacology
OTO - NOTNLM
OT  - Mangiferin
OT  - corticosterone
OT  - hippocampus
OT  - indoleamine 2,3-dioxygenase
OT  - neuroinflammation
OT  - oxido-nitrosative stress
EDAT- 2017/04/14 06:00
MHDA- 2018/04/18 06:00
CRDT- 2017/04/14 06:00
PHST- 2017/04/14 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/04/14 06:00 [entrez]
AID - 10.1080/01616412.2017.1310705 [doi]
PST - ppublish
SO  - Neurol Res. 2017 Aug;39(8):709-718. doi: 10.1080/01616412.2017.1310705. Epub 2017 
      Apr 12.