PMID- 2840377
OWN - NLM
STAT- MEDLINE
DCOM- 19880901
LR  - 20180216
IS  - 0301-0147 (Print)
IS  - 0301-0147 (Linking)
VI  - 18 Suppl 3
DP  - 1988
TI  - Experimental investigations on the thrombosis-preventing effect of 
      low-molecular-weight heparins.
PG  - 69-72
AB  - 6 different preparations of low-molecular-weight heparin (LMWH) derivatives and 1 
      unfractionated heparin (UFH) were tested for their thromboprophylactic effects in 
      an experimental model which closely simulates clinical conditions. Each 
      preparation was tested in 5 rabbits 2 h and in 5 rabbits 12 h after subcutaneous 
      application of 20-200 U/kg body weight (according to the suggestions of the 
      manufacturers). The animals were anesthetized with intravenous pentobarbital 
      sodium about 90 min or 11.5 h after the application of the heparin preparation. 
      The right external jugular vein was dissected free and a thrombogenesis was 
      provoked. There was no significant protection against occluding thrombosis 2 h 
      after LMWH or UFH injection, when plasma levels of heparin-like activities were 
      found to be high in another experimental series. Surprisingly, there were 
      definite thromboprophylactic effects 12 h (when heparin-like plasma activities 
      had disappeared) after application of 4 (out of 6) LMWH preparations. No 
      protection against thrombosis was seen 12 h after application of UFH.
FAU - Harbauer, G
AU  - Harbauer G
AD  - Department of Experimental Surgery, Saar University, Homburg/Saar, FRG.
FAU - Allendorf, A
AU  - Allendorf A
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Haemostasis
JT  - Haemostasis
JID - 0371574
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Animals
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Rabbits
MH  - Thrombosis/*prevention & control
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1159/000215870 [doi]
PST - ppublish
SO  - Haemostasis. 1988;18 Suppl 3:69-72. doi: 10.1159/000215870.