PMID- 2840379
OWN - NLM
STAT- MEDLINE
DCOM- 19880901
LR  - 20180216
IS  - 0301-0147 (Print)
IS  - 0301-0147 (Linking)
VI  - 18 Suppl 3
DP  - 1988
TI  - Prophylaxis of thromboembolism with various low-molecular-weight heparins.
PG  - 82-7
AB  - In numerous clinical studies, the antithrombotic effect and tolerance of 
      low-molecular-weight heparins (LMWHs) were compared to those of unfractionated 
      heparin (UFH). Based on our own experience and on a review of the literature the 
      following conclusions can be drawn. In the field of prophylaxis of 
      thromboembolism, including high-risk patients with major bone surgery, the 
      antithrombotic efficacy of a single daily dose of LMWH is at least equivalent to 
      two or three injections of UFH per day. It should, however, be noted that the 
      margin between thromboembolic and bleeding complications has not become bigger, 
      although this had been derived from experimental results. In order to avoid 
      bleeding complications, it is absolutely necessary to take note of the 
      manufacturers' recommendations. This is particularly important when a change of 
      various preparations is considered, because the standardization of LMWH 
      preparations is different and the units are not comparable. The main advantage of 
      LMWH results from an improved practicability. The single daily dose leads to an 
      improved compliance of patients and the nursing staff is spared a great deal of 
      work.
FAU - Haas, S
AU  - Haas S
AD  - Institute for Experimental Surgery, Technical University Munich, FRG.
FAU - Blumel, G
AU  - Blumel G
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Haemostasis
JT  - Haemostasis
JID - 0371574
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Bone and Bones/surgery
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Postoperative Complications/prevention & control
MH  - Risk Factors
MH  - Thromboembolism/*prevention & control
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1159/000215873 [doi]
PST - ppublish
SO  - Haemostasis. 1988;18 Suppl 3:82-7. doi: 10.1159/000215873.