PMID- 28405412
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2055-5660 (Print)
IS  - 2055-5660 (Electronic)
IS  - 2055-5660 (Linking)
VI  - 1
DP  - 2015
TI  - Serum haptoglobin dynamics in pigs vaccinated or not vaccinated against porcine 
      circovirus type 2.
PG  - 3
LID - 10.1186/2055-5660-1-3 [doi]
LID - 3
AB  - The present work describes the serum haptoglobin (Hp) dynamics in piglets 
      vaccinated and non-vaccinated with a commercial porcine circovirus type 2 (PCV2) 
      vaccine at 3 weeks of age, and its relationship with the average daily weight 
      gain (ADWG). The field study was carried out on two farms (A and B) with a 
      previous clinical history of PCV2-systemic disease (PCV2-SD). The aim of the 
      study was to assess whether Hp could be used as a surrogate marker of PCV2 
      vaccine efficacy. PCV2 infection was confirmed by quantitative real time PCR 
      (qPCR) in pigs from both farms, but PCV2-SD was only diagnosed in farm A. No 
      statistically significant relation was found between serum Hp concentration and 
      the percentage of qPCR positive animals and the treatment applied (PCV2 
      vaccination) in both farms. On the other hand, using linear regression analysis, 
      a significant negative correlation between the area under the curve of Hp 
      (AUC(Hp)) and ADWG was observed for farm A (p < 0.00001) and B (p = 0.01). Based 
      on the obtained determination coefficient (R(2)) values, AUC(Hp) explained 20.0 
      and 11.6% of the observed ADWG for farms A and B, respectively. The present study 
      supports that the measurement of acute phase proteins may be an indicator of ADWG 
      in pig farms, but it was not apparently feasible to use the serum Hp 
      concentration as a surrogate marker of PCV2 vaccine efficacy.
FAU - Fraile, Lorenzo
AU  - Fraile L
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra (Cerdanyola del Valles), 08193 Barcelona, 
      Spain.
AD  - Departament de Produccio Animal, ETSEA, Universitat de Lleida, 25198 Lleida, 
      Spain. GRID: grid.15043.33. ISNI: 0000000121631432
FAU - Saco, Yolanda
AU  - Saco Y
AD  - Servei de Bioquimica Clinica Veterinaria, Departament de Bioquimica i Biologia 
      Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra 
      (Cerdanyola del Valles), 08193 Barcelona, Spain. GRID: grid.7080.f
FAU - Grau-Roma, Llorenc
AU  - Grau-Roma L
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra (Cerdanyola del Valles), 08193 Barcelona, 
      Spain.
AD  - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 
      Bellaterra (Cerdanyola del Valles), 08193 Barcelona, Spain. GRID: grid.7080.f
FAU - Nofrarias, Miquel
AU  - Nofrarias M
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra (Cerdanyola del Valles), 08193 Barcelona, 
      Spain.
FAU - Lopez-Soria, Sergio
AU  - Lopez-Soria S
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra (Cerdanyola del Valles), 08193 Barcelona, 
      Spain.
FAU - Sibila, Marina
AU  - Sibila M
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra (Cerdanyola del Valles), 08193 Barcelona, 
      Spain.
FAU - Callen, Antonio
AU  - Callen A
AD  - Merial Laboratories, Barcelona, Spain.
FAU - Bassols, Anna
AU  - Bassols A
AD  - Servei de Bioquimica Clinica Veterinaria, Departament de Bioquimica i Biologia 
      Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra 
      (Cerdanyola del Valles), 08193 Barcelona, Spain. GRID: grid.7080.f
FAU - Segales, Joaquim
AU  - Segales J
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra (Cerdanyola del Valles), 08193 Barcelona, 
      Spain.
AD  - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 
      Bellaterra (Cerdanyola del Valles), 08193 Barcelona, Spain. GRID: grid.7080.f
LA  - eng
PT  - Journal Article
DEP - 20150416
PL  - England
TA  - Porcine Health Manag
JT  - Porcine health management
JID - 101684126
PMC - PMC5375125
OTO - NOTNLM
OT  - Acute phase proteins
OT  - Average daily weight gain
OT  - PCV2 inactivated vaccine
OT  - Porcine circovirus type 2-systemic disease (PCV2-SD)
EDAT- 2015/04/16 00:00
MHDA- 2015/04/16 00:01
PMCR- 2015/04/16
CRDT- 2017/04/14 06:00
PHST- 2014/07/08 00:00 [received]
PHST- 2014/10/23 00:00 [accepted]
PHST- 2017/04/14 06:00 [entrez]
PHST- 2015/04/16 00:00 [pubmed]
PHST- 2015/04/16 00:01 [medline]
PHST- 2015/04/16 00:00 [pmc-release]
AID - 3 [pii]
AID - 10.1186/2055-5660-1-3 [doi]
PST - epublish
SO  - Porcine Health Manag. 2015 Apr 16;1:3. doi: 10.1186/2055-5660-1-3. eCollection 
      2015.