PMID- 28405502
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 6
IP  - 3
DP  - 2017
TI  - IL4-induced gene 1 promotes tumor growth by shaping the immune microenvironment 
      in melanoma.
PG  - e1278331
LID - 10.1080/2162402X.2016.1278331 [doi]
LID - e1278331
AB  - Amino acid catabolizing enzymes emerged as a crucial mechanism used by tumors to 
      dampen immune responses. The L-phenylalanine oxidase IL-4 induced gene 1 (IL4I1) 
      is expressed by tumor-associated myeloid cells of most solid tumors, including 
      melanoma. We previously provided the only evidence that IL4I1 accelerates tumor 
      growth by limiting the CD8(+) T cell mediated immune response, in a mouse model 
      of melanoma cell transplantation. Here, we explored the role of IL4I1 in Ret 
      mice, a spontaneous model of melanoma. We found that IL4I1 was expressed by 
      CD11b(+) myeloid cells and that its activity correlated with disease 
      aggressiveness. IL4I1 did not enhance tumor cell proliferation or angiogenesis, 
      but orchestrated the remodeling of the immune compartment within the primary 
      tumor. Indeed, the inactivation of IL4I1 limited the recruitment of 
      polymorphonuclear myeloid-derived suppressor cells and enhanced the infiltration 
      by Th1 and cytotoxic T cells, thus delaying tumor development and metastatic 
      dissemination. Accordingly, human primary melanomas that were poorly infiltrated 
      by IL4I1(+) cells exhibited a higher density of CD8(+) T cells. Collectively, our 
      findings strengthen the rationale for therapeutic targeting of IL4I1 as one of 
      the key immune regulators.
FAU - Bod, Lloyd
AU  - Bod L
AD  - Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Lengagne, Renee
AU  - Lengagne R
AD  - Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Wrobel, Ludovic
AU  - Wrobel L
AD  - Hopitaux Universitaires de Geneve , Geneve, Switzerland.
FAU - Ramspott, Jan Philipp
AU  - Ramspott JP
AD  - Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
FAU - Kato, Masashi
AU  - Kato M
AD  - Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan.
FAU - Avril, Marie-Francoise
AU  - Avril MF
AD  - Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France; APHP, Hopital 
      Cochin, Paris, France.
FAU - Castellano, Flavia
AU  - Castellano F
AD  - INSERM, U955, Equipe 09, Creteil, France; Universite Paris Est, Faculte de 
      Medecine, Creteil, France; AP-HP, Hopital H. Mondor - A. Chenevier, Plateforme de 
      Ressources Biologiques, Creteil, France.
FAU - Molinier-Frenkel, Valerie
AU  - Molinier-Frenkel V
AD  - INSERM, U955, Equipe 09, Creteil, France; Universite Paris Est, Faculte de 
      Medecine, Creteil, France; AP-HP, Hopital H. Mondor - A. Chenevier, Service 
      d'Immunologie Biologique, Creteil, France.
FAU - Prevost-Blondel, Armelle
AU  - Prevost-Blondel A
AD  - Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; 
      Universite Paris Descartes, Sorbonne Paris Cite, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170113
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC5384381
OTO - NOTNLM
OT  - CD8+ T cells
OT  - IL4I1
OT  - primary melanoma
OT  - tumor escape
EDAT- 2017/04/14 06:00
MHDA- 2017/04/14 06:01
PMCR- 2018/01/13
CRDT- 2017/04/14 06:00
PHST- 2016/11/22 00:00 [received]
PHST- 2016/12/21 00:00 [revised]
PHST- 2016/12/28 00:00 [accepted]
PHST- 2017/04/14 06:00 [entrez]
PHST- 2017/04/14 06:00 [pubmed]
PHST- 2017/04/14 06:01 [medline]
PHST- 2018/01/13 00:00 [pmc-release]
AID - 1278331 [pii]
AID - 10.1080/2162402X.2016.1278331 [doi]
PST - epublish
SO  - Oncoimmunology. 2017 Jan 13;6(3):e1278331. doi: 10.1080/2162402X.2016.1278331. 
      eCollection 2017.