PMID- 28406702
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20220331
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 66
IP  - 4
DP  - 2017 Sep 22
TI  - An alternatively activated macrophage marker CD163 in severely obese patients: 
      the influence of very low-calorie diet and bariatric surgery.
PG  - 641-652
AB  - CD163 is a marker of macrophages with anti-inflammatory properties and its 
      soluble form (sCD163) is considered a prognostic predictor of several diseases 
      including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline 
      and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with 
      obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with 
      T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We 
      also assessed the changes of CD163 positive cells of monocyte-macrophage lineage 
      in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients. 
      Plasma sCD163 levels were increased in obese and T2DM subjects relative to 
      control subjects (467.2+/-40.2 and 513.8+/-37.0 vs. 334.4+/-24.8 ng/ml, p=0.001) 
      and decreased after both interventions. Obesity decreased percentage of 
      CD163+CD14+ monocytes in peripheral blood compared to controls (78.9+/-1.48 vs. 
      86.2+/-1.31 %, p=0.003) and bariatric surgery decreased CD163+CD14+HLA-DR+ 
      macrophages in SAT (19.4+/-2.32 vs. 11.3+/-0.90 %, p=0.004). Our data suggest 
      that increased basal sCD163 levels are related to obesity and its metabolic 
      complications. On the contrary, sCD163 or CD163 positive cell changes do not 
      precisely reflect metabolic improvements after weight loss.
FAU - Cinkajzlova, A
AU  - Cinkajzlova A
AD  - Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University 
      and General University Hospital, Prague, Czech Republic, Centre for Experimental 
      Medicine and Diabetes Centre, Institute for Clinical and Experimental Medicine, 
      Prague, Czech Republic. halm@ikem.cz.
FAU - Lacinova, Z
AU  - Lacinova Z
FAU - Klouckova, J
AU  - Klouckova J
FAU - Kavalkova, P
AU  - Kavalkova P
FAU - Trachta, P
AU  - Trachta P
FAU - Kosak, M
AU  - Kosak M
FAU - Kratky, J
AU  - Kratky J
FAU - Kasalicky, M
AU  - Kasalicky M
FAU - DoleZalova, K
AU  - DoleZalova K
FAU - Mraz, M
AU  - Mraz M
FAU - Haluzik, M
AU  - Haluzik M
LA  - eng
PT  - Journal Article
DEP - 20170412
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (CD163 antigen)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*blood
MH  - Antigens, Differentiation, Myelomonocytic/*blood
MH  - Bariatric Surgery/*trends
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Caloric Restriction/*trends
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/therapy
MH  - Female
MH  - Humans
MH  - Macrophages/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/diagnosis/*therapy
MH  - Receptors, Cell Surface/*blood
EDAT- 2017/04/14 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/04/14 06:00
PHST- 2017/04/14 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/04/14 06:00 [entrez]
AID - 933522 [pii]
AID - 10.33549/physiolres.933522 [doi]
PST - ppublish
SO  - Physiol Res. 2017 Sep 22;66(4):641-652. doi: 10.33549/physiolres.933522. Epub 
      2017 Apr 12.