PMID- 28407658
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20211103
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 125
IP  - 5
DP  - 2017 May
TI  - Effect of Carnosine on Renal Function, Oxidation and Glycation Products in the 
      Kidneys of High-Fat Diet/Streptozotocin-Induced Diabetic Rats.
PG  - 282-289
LID - 10.1055/s-0043-100117 [doi]
AB  - High fat diet (HFD) and low dose of streptozotocin (STZ)-treated rats provide an 
      animal model for type 2 Diabetes Mellitus (T2DM). Oxidative stress plays a role 
      in the development of diabetic complications. Carnosine (CAR) has antioxidant and 
      antiglycating properties. We investigated effects of CAR on renal function, 
      oxidation and glycation products in HFD+STZ-rats. Rats were fed with HFD (60% of 
      total calories from fat) for 4 weeks and then a single dose STZ (40 mg/kg; i.p.) 
      was applied. Rats with blood glucose levels above 200 mg/dL were fed with HFD 
      until the end of the 12(th) week. CAR (250 mg/kg body weight; i.p.; 5 times a 
      week) was administered to rats for the last 4 weeks. Glycated hemoglobin (HbA1c), 
      glucose, lipids, and andrenal function tests in serum as well as reactive oxygen 
      species, malondialdehyde, protein carbonyl, advanced oxidation protein products, 
      advanced glycation end products (AGEs), antioxidant power, and antioxidant enzyme 
      activities and their mRNA expressions in kidneys were determined. CAR treatment 
      did not alter glucose and HbA1c, but it decreased serum lipids, creatinine, and 
      urea levels in HFD+STZ rats. Oxidation products of lipids and proteins and AGEs 
      levels decreased, but antioxidant enzyme activities and their mRNA expressions 
      remained unchanged due to CAR treatment. Our results indicate that CAR treatment 
      alleviated renal function and decreased accumulation of oxidation and glycation 
      products in kidneys in HFD+STZ-rats.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Fatih Aydin, Abdurrahman
AU  - Fatih Aydin A
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Kucukgergin, Canan
AU  - Kucukgergin C
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Bingul, Ilknur
AU  - Bingul I
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Dogan-Ekici, Isin
AU  - Dogan-Ekici I
AD  - Department of Pathology, Yeditepe University Medical Faculty, Kayisdagi, 
      Istanbul, Turkey.
FAU - Dogru-Abbasoglu, Semra
AU  - Dogru-Abbasoglu S
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Uysal, Mujdat
AU  - Uysal M
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170413
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Dietary Fats)
RN  - 0 (Glycation End Products, Advanced)
RN  - 8HO6PVN24W (Carnosine)
SB  - IM
MH  - Animals
MH  - Carnosine/*pharmacology
MH  - Diabetes Mellitus, Experimental/*metabolism/pathology
MH  - Dietary Fats/*adverse effects/pharmacology
MH  - Glycation End Products, Advanced/*metabolism
MH  - Kidney/*metabolism/pathology
MH  - Kidney Function Tests
MH  - Male
MH  - Rats
MH  - Rats, Wistar
COIS- Conflict of interest: None.
EDAT- 2017/04/14 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/04/14 06:00
PHST- 2017/04/14 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/04/14 06:00 [entrez]
AID - 10.1055/s-0043-100117 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2017 May;125(5):282-289. doi: 
      10.1055/s-0043-100117. Epub 2017 Apr 13.