PMID- 28407692
OWN - NLM
STAT- MEDLINE
DCOM- 20170929
LR  - 20220408
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 11
DP  - 2017 Mar 14
TI  - MicroRNA-137 inhibits BMP7 to enhance the epithelial-mesenchymal transition of 
      breast cancer cells.
PG  - 18348-18358
LID - 10.18632/oncotarget.15442 [doi]
AB  - Bone morphogenetic protein-7 (BMP7) is known to antagonize transforming growth 
      factor beta 1 (TGFbeta1)-mediated fibrosis through suppressing epithelial-mesenchymal 
      transition (EMT). We recently reported that BMP7 also antagonizes the effects of 
      TGFbeta1 in breast cancer (BC) tumorigenesis-related EMT. Nevertheless, the control 
      of BMP7 expression in BC remains ill-defined. Here, we detected significantly 
      lower levels of BMP7 and significantly higher levels of microRNA-137 (miR-137) in 
      the BC specimens, relative to paired adjacent non-tumor breast tissue. BMP7 and 
      miR-137 levels were correlated inversely. Additionally, the high miR-137 levels 
      in BC specimens were correlated with reduced patient survival. In vitro, 
      overexpression of miR-137 significantly increased cell EMT and invasion, while 
      depletion of miR-137 significantly decreased cell EMT and invasion in BC cells. 
      The increases in BC cell invasiveness by miR-137 appeared to result from its 
      suppression of BMP7, through direct binding of miR-137 to the 3'-UTR of BMP7 
      mRNA, thereby blocking its protein translation in BC cells. This study sheds 
      light on miR-137 as a crucial factor that enhances BC cell EMT and invasiveness, 
      and points to miR-137 as a promising innovative therapeutic target for BC 
      treatment.
FAU - Ying, Xuexiang
AU  - Ying X
AD  - Department of General Surgery, Shanghai Jiaotong University Affiliated Sixth 
      People's Hospital, 200233, China.
FAU - Sun, Yunpo
AU  - Sun Y
AD  - Department of General Surgery, Shanghai Jiaotong University Affiliated Sixth 
      People's Hospital, 200233, China.
FAU - He, Pingqing
AU  - He P
AD  - Department of General Surgery, Shanghai Jiaotong University Affiliated Sixth 
      People's Hospital, 200233, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (BMP7 protein, human)
RN  - 0 (Bone Morphogenetic Protein 7)
RN  - 0 (MIRN137 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Bone Morphogenetic Protein 7/*antagonists & inhibitors/genetics/metabolism
MH  - Breast Neoplasms/genetics/*metabolism/*pathology
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Female
MH  - Humans
MH  - MCF-7 Cells
MH  - MicroRNAs/genetics/*metabolism
MH  - Middle Aged
MH  - RNA, Messenger/genetics/metabolism
PMC - PMC5392333
OTO - NOTNLM
OT  - bone morphogenetic protein-7 (BMP7)
OT  - breast cancer (BC)
OT  - epithelial-mesenchymal transition (EMT)
OT  - miR-137
COIS- CONFLICTS OF INTEREST The authors declare no conflicts of interest.
EDAT- 2017/04/15 06:00
MHDA- 2017/09/30 06:00
PMCR- 2017/03/14
CRDT- 2017/04/15 06:00
PHST- 2016/12/06 00:00 [received]
PHST- 2017/01/11 00:00 [accepted]
PHST- 2017/04/15 06:00 [entrez]
PHST- 2017/04/15 06:00 [pubmed]
PHST- 2017/09/30 06:00 [medline]
PHST- 2017/03/14 00:00 [pmc-release]
AID - 15442 [pii]
AID - 10.18632/oncotarget.15442 [doi]
PST - ppublish
SO  - Oncotarget. 2017 Mar 14;8(11):18348-18358. doi: 10.18632/oncotarget.15442.