PMID- 28408294
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20180823
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 77
DP  - 2017 Jul 3
TI  - Resilience and cross-network connectivity: A neural model for post-trauma 
      survival.
PG  - 110-119
LID - S0278-5846(16)30271-8 [pii]
LID - 10.1016/j.pnpbp.2017.04.010 [doi]
AB  - Literature on the neurobiological bases of Post-Traumatic Stress Disorder (PTSD) 
      considers medial Prefrontal cortex (mPFC), a core region of the Default Mode 
      Network (DMN), as a region involved in response regulation to stressors. 
      Disrupted functioning of the DMN has been recognized at the basis of the 
      pathophysiology of a number of mental disorders. Furthermore, in the evaluation 
      of the protective factors to trauma consequence, an important role has been 
      assigned to resilience. Our aim was to investigate the specific relation of 
      resilience and PTSD symptoms severity with resting state brain connectivity in a 
      traumatized population using magnetoencephalography (MEG), a non-invasive imaging 
      technique with high temporal resolution and documented advantages in clinical 
      applications. Nineteen Trauma Exposed non-PTSD (TENP) and 19 PTSD patients 
      participated to a resting state MEG session. MEG functional connectivity of mPFC 
      seed to the whole brain was calculated. Correlation between mPFC functional 
      connectivity and Clinician Administered PTSD Scale (CAPS) or Connor-Davidson 
      Resilience Scale (CD-RISC) total score was also assessed. In the whole group, it 
      has been evidenced that the higher was the resilience, the lower was the 
      cross-network connectivity between DMN and Salience Network (SN) nodes. 
      Contrarily, in the TENP group, the negative correlation between resilience and 
      DMN-SN cross-interaction disappeared, suggesting a protective role of resilience 
      for brain functioning. Regarding our findings as a continuum between healthy and 
      pathological after trauma outcomes, we could suggest a link between resilience 
      and the good dialogue between the networks needed to face a traumatic event and 
      its long-term consequence on individuals' lives.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Brunetti, Marcella
AU  - Brunetti M
AD  - Institute for Advanced Biomedical Technologies, University of Chieti, Italy; 
      Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy. Electronic address: mbrunetti@itab.unich.it.
FAU - Marzetti, Laura
AU  - Marzetti L
AD  - Institute for Advanced Biomedical Technologies, University of Chieti, Italy; 
      Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy.
FAU - Sepede, Gianna
AU  - Sepede G
AD  - Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy; Department of Basic Medical Sciences, Neurosciences and Sense Organs, 
      University of Bari, Italy.
FAU - Zappasodi, Filippo
AU  - Zappasodi F
AD  - Institute for Advanced Biomedical Technologies, University of Chieti, Italy; 
      Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy.
FAU - Pizzella, Vittorio
AU  - Pizzella V
AD  - Institute for Advanced Biomedical Technologies, University of Chieti, Italy; 
      Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy.
FAU - Sarchione, Fabiola
AU  - Sarchione F
AD  - Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy.
FAU - Vellante, Federica
AU  - Vellante F
AD  - Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy.
FAU - Martinotti, Giovanni
AU  - Martinotti G
AD  - Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy.
FAU - Di Giannantonio, Massimo
AU  - Di Giannantonio M
AD  - Department of Neuroscience, Imaging & Clinical Science, University of Chieti, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170410
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Magnetoencephalography
MH  - Male
MH  - Neural Pathways/*physiopathology
MH  - *Resilience, Psychological
MH  - Rest
MH  - Stress Disorders, Post-Traumatic/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Default Mode Network (DMN)
OT  - Magnetoencephalography (MEG)
OT  - PTSD
OT  - Resilience
OT  - Resting state functional connectivity (RSFC)
OT  - Salience Network (SN)
EDAT- 2017/04/15 06:00
MHDA- 2018/03/06 06:00
CRDT- 2017/04/15 06:00
PHST- 2016/10/04 00:00 [received]
PHST- 2017/03/24 00:00 [revised]
PHST- 2017/04/08 00:00 [accepted]
PHST- 2017/04/15 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/04/15 06:00 [entrez]
AID - S0278-5846(16)30271-8 [pii]
AID - 10.1016/j.pnpbp.2017.04.010 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:110-119. doi: 
      10.1016/j.pnpbp.2017.04.010. Epub 2017 Apr 10.