PMID- 28409762
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20181202
IS  - 1878-4429 (Electronic)
IS  - 1878-4429 (Linking)
VI  - 10
IP  - 2
DP  - 2017
TI  - Readmission for neonatal hyperbilirubinemia in an area with a high prevalence of 
      glucose-6-phosphate dehydrogenase deficiency: A hospital-based retrospective 
      study.
PG  - 181-189
LID - 10.3233/NPM-171696 [doi]
AB  - BACKGROUND: Hyperbilirubinemia is one of the most common causes of neonatal 
      readmission to hospital. AIMS: To assess risk factors for hyperbilirubinemia 
      among neonates readmitted for this condition and the ratio of the mean 
      corpuscular hemoglobin concentration (MCHC) to the mean corpuscular volume (MCV). 
      METHODS: We retrospectively studied the clinical and laboratory findings, 
      management and possible risk factors for hyperbilirubinemia in 301 neonates born 
      at >/=35 weeks gestation and readmitted to hospital owing to hyperbilirubinemia 
      over five years. RESULTS: No risk factors for hyperbilirubinemia were identified 
      in 64 (21.3%) neonates, and one or more risk factors were found in 237 neonates 
      (78.7%). The most prevalent risk factor (41.9%) was G6PD deficiency, which 
      occurred in 11 of the 15 neonates with a serum bilirubin level >/=427 mumol/l. A 
      double-volume exchange blood transfusion was performed in two neonate boys in 
      whom G6PD deficiency was the single risk factor for hyperbilirubinemia. One of 
      them developed kernicterus later. The MCHC/MCV ratio of neonates with idiopathic 
      hyperbilirubinemia, unexplained hemolysis, or other risk factors overlapped. 
      CONCLUSIONS: This study confirmed that in an area where G6PD deficiency is 
      prevalent, it is the most common and most severe risk factor for 
      hyperbilirubinemia. This finding supports routine neonatal screening for G6PD 
      deficiency in such areas. The usefulness of determining the MCHC/MCV ratio in the 
      management of hyperbilirubinemia is uncertain.
FAU - Al-Omran, A
AU  - Al-Omran A
AD  - Department of Pediatrics, Almana General Hospital, Al-Ahsa, Saudi Arabia.
FAU - Al-Abdi, S
AU  - Al-Abdi S
AD  - Department of Pediatrics, King Abdulaziz Hospital, Ministry of National Guard 
      Hospital, Al-Ahsa, Saudi Arabia.
FAU - Al-Salam, Z
AU  - Al-Salam Z
AD  - Department of Pediatrics, Oasis Hospital, Al-Ain, United Arab Emirates.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Neonatal Perinatal Med
JT  - Journal of neonatal-perinatal medicine
JID - 101468335
SB  - IM
MH  - Exchange Transfusion, Whole Blood/statistics & numerical data
MH  - Female
MH  - Glucosephosphate Dehydrogenase Deficiency/*complications/*epidemiology/therapy
MH  - Hospitals
MH  - Humans
MH  - Hyperbilirubinemia, Neonatal/*epidemiology/*etiology/therapy
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Neonatal Screening
MH  - Patient Readmission/*statistics & numerical data
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Saudi Arabia/epidemiology
OTO - NOTNLM
OT  - Neonatal hyperbilirubinemia
OT  - erythrocyte indices
OT  - glucose-6-phosphate dehydrogenase deficiency
OT  - hereditary spherocytosis
OT  - phototherapy
EDAT- 2017/04/15 06:00
MHDA- 2018/05/03 06:00
CRDT- 2017/04/15 06:00
PHST- 2017/04/15 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
PHST- 2017/04/15 06:00 [entrez]
AID - NPM1696 [pii]
AID - 10.3233/NPM-171696 [doi]
PST - ppublish
SO  - J Neonatal Perinatal Med. 2017;10(2):181-189. doi: 10.3233/NPM-171696.