PMID- 28410479
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20191210
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1053
DP  - 2017 May 15
TI  - Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal 
      matrices with multi-plug filtration cleanup by liquid chromatography-tandem mass 
      spectrometry detection.
PG  - 27-33
LID - S1570-0232(16)30794-2 [pii]
LID - 10.1016/j.jchromb.2017.04.006 [doi]
AB  - The frequent use of various veterinary drugs could lead to residue 
      bioaccumulation in animal tissues, which could cause dietary risks to human 
      health. In order to quickly analyze the residues, a liquid chromatography tandem 
      mass spectrometry (LC-MS/MS) method was developed for detecting Sulfonamides, 
      Tilmicosin and Avermectins (AVMs) residues in animal samples. For sample 
      preparation, modified QuEChERS (quick, easy, cheap, effective, rugged and safe) 
      and ultrasound-assisted extraction (UAE) methods were used. For sample cleanup, 
      n-Hexane delipidation and multi-plug filtration cleanup (m-PFC) method based on 
      primary-secondary amine (PSA) and octadecyl-silica (C18) were used, followed by 
      LC-MS/MS analysis. It was validated on 7 animal matrices (bovine, caprine, swine 
      meat and their kidneys, milk) at two fortified concentration levels of 5 and 
      100mug/kg. The recoveries ranged from 82 to 107% for all analytes with relative 
      standard deviations (RSDs) less than 15%. Matrix-matched calibrations were 
      performed with coefficients of determination above 0.998 for all analytes within 
      concentration levels of 5-500mug/kg. The developed method was successfully used to 
      analysis veterinary drugs of real animal samples from local markets.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Qin, Yuhong
AU  - Qin Y
AD  - Department of Applied Chemistry, College of Science, China Agricultural 
      University, Beijing, China.
FAU - Jatamunua, Freedom
AU  - Jatamunua F
AD  - Central Veterinary Laboratory, Ministry of Agriculture, Water and Forestry, 
      Windhoek, Namibia.
FAU - Zhang, Jingru
AU  - Zhang J
AD  - Department of Applied Chemistry, College of Science, China Agricultural 
      University, Beijing, China.
FAU - Li, Yanjie
AU  - Li Y
AD  - Department of Applied Chemistry, College of Science, China Agricultural 
      University, Beijing, China.
FAU - Han, Yongtao
AU  - Han Y
AD  - Department of Applied Chemistry, College of Science, China Agricultural 
      University, Beijing, China.
FAU - Zou, Nan
AU  - Zou N
AD  - Department of Applied Chemistry, College of Science, China Agricultural 
      University, Beijing, China.
FAU - Shan, Jihao
AU  - Shan J
AD  - Institute of Agro-Products Processing Science & Technology, Chinese Academy of 
      Agricultural Sciences (CAAS), Beijing, China.
FAU - Jiang, Yanbin
AU  - Jiang Y
AD  - China Animal Disease Control Center (CADC), Beijing, China.
FAU - Pan, Canping
AU  - Pan C
AD  - Department of Applied Chemistry, College of Science, China Agricultural 
      University, Beijing, China. Electronic address: canpingp@cau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20170402
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Hexanes)
RN  - 0 (Sulfonamides)
RN  - 0 (Veterinary Drugs)
RN  - 2DDG612ED8 (n-hexane)
RN  - 70288-86-7 (Ivermectin)
RN  - 73989-17-0 (avermectin)
RN  - XL4103X2E3 (tilmicosin)
RN  - YEF4JXN031 (Tylosin)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/*analysis
MH  - Cattle
MH  - Chromatography, High Pressure Liquid/methods
MH  - Filtration/methods
MH  - Food Analysis/methods
MH  - Food Contamination
MH  - Goats
MH  - Hexanes/chemistry
MH  - Humans
MH  - Ivermectin/*analogs & derivatives/analysis
MH  - Limit of Detection
MH  - Meat/*analysis
MH  - Milk/*chemistry
MH  - Sonication/methods
MH  - Sulfonamides/*analysis
MH  - Swine
MH  - Tandem Mass Spectrometry/methods
MH  - Tylosin/*analogs & derivatives/analysis
MH  - Veterinary Drugs/*analysis
OTO - NOTNLM
OT  - Animal matrices
OT  - Multi-plug filtration cleanup
OT  - Residues analysis
OT  - Veterinary drugs
EDAT- 2017/04/15 06:00
MHDA- 2017/06/01 06:00
CRDT- 2017/04/15 06:00
PHST- 2016/09/06 00:00 [received]
PHST- 2017/03/28 00:00 [revised]
PHST- 2017/04/01 00:00 [accepted]
PHST- 2017/04/15 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2017/04/15 06:00 [entrez]
AID - S1570-0232(16)30794-2 [pii]
AID - 10.1016/j.jchromb.2017.04.006 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 15;1053:27-33. doi: 
      10.1016/j.jchromb.2017.04.006. Epub 2017 Apr 2.