PMID- 28410520 OWN - NLM STAT- MEDLINE DCOM- 20170623 LR - 20240326 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 156 DP - 2017 Jul TI - Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort. PG - 426-433 LID - S0013-9351(16)31238-5 [pii] LID - 10.1016/j.envres.2017.03.056 [doi] AB - INTRODUCTION: Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking. METHODS: We examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood. We assessed a multiplexed panel of circulating inflammatory and endothelial function markers, including tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant protein 1 (MCP1), intercellular adhesion molecule (ICAM1) and vascular cell adhesion molecule (VCAM1). RESULTS: Compared with the bottom tertile, the highest tertile of maternal urinary As during pregnancy was associated with a 145.2ng/ml (95% CI 4.1, 286.3; p=0.04) increase in cord blood ICAM1 and 557.3ng/ml (95% CI -56.4, 1171.1; p=0.09) increase in cord blood VCAM1. Among mothers, the highest tertile of maternal urinary As during pregnancy was related to a 141.8ng/ml (95% CI 26.1, 257.5; p=0.02) increase maternal plasma VCAM1 levels. Urinary As was unrelated to MCP1 or TNFalpha in maternal plasma and cord blood. In structural equation models, the association between maternal urinary As and infant VCAM was mediated by maternal levels of VCAM (beta(mediation): 0.024, 95% CI: 0.002, 0.050). CONCLUSION: Our observations indicate that As exposure during pregnancy may affect markers of vascular health and endothelial function in both pregnant women and children, and suggest further investigation of the potential impacts on cardiovascular health in these susceptible populations. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Farzan, Shohreh F AU - Farzan SF AD - Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: sffarzan@usc.edu. FAU - Brickley, Elizabeth B AU - Brickley EB AD - Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Li, Zhigang AU - Li Z AD - Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Gilbert-Diamond, Diane AU - Gilbert-Diamond D AD - Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Gossai, Anala AU - Gossai A AD - Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Chen, Yu AU - Chen Y AD - Department of Population Health, New York University School of Medicine, New York, NY, USA. FAU - Howe, Caitlin G AU - Howe CG AD - Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. FAU - Palys, Thomas AU - Palys T AD - Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Karagas, Margaret R AU - Karagas MR AD - Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. LA - eng GR - P30 ES007048/ES/NIEHS NIH HHS/United States GR - UH3 OD023275/OD/NIH HHS/United States GR - P42 ES007373/ES/NIEHS NIH HHS/United States GR - R00 ES024144/ES/NIEHS NIH HHS/United States GR - P30 CA023108/CA/NCI NIH HHS/United States GR - P01 ES022832/ES/NIEHS NIH HHS/United States GR - R25 CA134286/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20170412 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Biomarkers) RN - N712M78A8G (Arsenic) SB - IM MH - Adolescent MH - Adult MH - Arsenic/blood/*toxicity/urine MH - Biomarkers/blood/urine MH - Cohort Studies MH - Endothelium/*drug effects MH - Female MH - Fetal Blood/*chemistry MH - Humans MH - Infant, Newborn MH - Inflammation/blood/chemically induced/epidemiology/urine MH - Male MH - *Maternal Exposure MH - Middle Aged MH - New Hampshire/epidemiology MH - Pregnancy MH - Prenatal Exposure Delayed Effects/blood/*chemically induced/epidemiology/urine MH - Young Adult PMC - PMC5477637 MID - NIHMS867743 OTO - NOTNLM OT - Arsenic OT - Endothelial OT - Inflammatory markers OT - New Hampshire OT - Pregnancy cohort COIS- The authors have no competing personal or financial interests. All participants provided written, informed consent upon enrollment. All protocols were approved by the Dartmouth College Institutional Review Board (Dartmouth Committee for the Protection of Human Subjects Approval Reference #20844). EDAT- 2017/04/15 06:00 MHDA- 2017/06/24 06:00 PMCR- 2018/07/01 CRDT- 2017/04/15 06:00 PHST- 2016/12/13 00:00 [received] PHST- 2017/03/27 00:00 [revised] PHST- 2017/03/30 00:00 [accepted] PHST- 2017/04/15 06:00 [pubmed] PHST- 2017/06/24 06:00 [medline] PHST- 2017/04/15 06:00 [entrez] PHST- 2018/07/01 00:00 [pmc-release] AID - S0013-9351(16)31238-5 [pii] AID - 10.1016/j.envres.2017.03.056 [doi] PST - ppublish SO - Environ Res. 2017 Jul;156:426-433. doi: 10.1016/j.envres.2017.03.056. Epub 2017 Apr 12.