PMID- 28411140
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20181113
IS  - 2352-3964 (Electronic)
IS  - 2352-3964 (Linking)
VI  - 18
DP  - 2017 Apr
TI  - Batf3-dependent CD8alpha(+) Dendritic Cells Aggravates Atherosclerosis via Th1 Cell 
      Induction and Enhanced CCL5 Expression in Plaque Macrophages.
PG  - 188-198
LID - S2352-3964(17)30151-2 [pii]
LID - 10.1016/j.ebiom.2017.04.008 [doi]
AB  - Dendritic cells (DCs) play an important role in controlling T cell-mediated 
      adaptive immunity in atherogenesis. However, the role of the basic leucine zipper 
      transcription factor, ATF-like 3 (Batf3)-dependent CD8alpha(+) DC subset in 
      atherogenesis remains unclear. Here we show that Batf3(-/-)Apoe(-/-) mice, 
      lacking CD8alpha(+) DCs, exhibited a significant reduction in atherogenesis and T 
      help 1 (Th1) cells compared with Apoe(-/-) controls. Then, we found that CD8alpha(+) 
      DCs preferentially induce Th1 cells via secreting interleukin-12 (IL-12), and 
      that the expression of interferon-gamma (IFN-gamma)or chemokine (C-C motif) ligand 5 
      (CCL5) in aorta were significantly decreased in Batf3(-/-)Apoe(-/-) mice. We 
      further demonstrated that macrophages were the major CCL5-expressing cells in the 
      plaque, which was significantly reduced in Batf3(-/-)Apoe(-/-) mice. Furthermore, 
      we found CCL5 expression in macrophages was promoted by IFN-gamma. Finally, we showed 
      that Batf3(-/-)Apoe(-/-) mice displayed decreased infiltration of leukocytes in 
      the plaque. Thus, CD8alpha(+) DCs aggravated atherosclerosis, likely by inducing Th1 
      cell response, which promoted CCL5 expression in macrophages and increased 
      infiltration of leukocytes and lesion inflammation.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Li, Yalin
AU  - Li Y
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China.
FAU - Liu, Xueyan
AU  - Liu X
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China.
FAU - Duan, Wei
AU  - Duan W
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China.
FAU - Tian, Hua
AU  - Tian H
AD  - Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of 
      Atherosclerosis, Taishan Medical University, Shandong, China.
FAU - Zhu, Guangming
AU  - Zhu G
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China.
FAU - He, Hao
AU  - He H
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China.
FAU - Yao, Shutong
AU  - Yao S
AD  - Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of 
      Atherosclerosis, Taishan Medical University, Shandong, China.
FAU - Yi, Shuying
AU  - Yi S
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China.
FAU - Song, Wengang
AU  - Song W
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China. 
      Electronic address: wgsong@tsmc.edu.cn.
FAU - Tang, Hua
AU  - Tang H
AD  - Institute of Immunology, Taishan Medical University, Taian, Shandong, China. 
      Electronic address: htang@tsmc.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170406
PL  - Netherlands
TA  - EBioMedicine
JT  - EBioMedicine
JID - 101647039
RN  - 0 (Apolipoproteins E)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8 antigen, alpha chain)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Repressor Proteins)
RN  - 0 (SNFT protein, mouse)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Apolipoproteins E/deficiency/genetics/metabolism
MH  - Atherosclerosis/metabolism/*pathology
MH  - Basic-Leucine Zipper Transcription Factors/deficiency/genetics/*metabolism
MH  - CD8 Antigens/*metabolism
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Chemokine CCL5/*metabolism
MH  - Dendritic Cells/cytology/*metabolism
MH  - Female
MH  - Interferon-gamma/metabolism
MH  - Interleukin-12/metabolism
MH  - Macrophages/cytology/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Repressor Proteins/deficiency/genetics/*metabolism
MH  - Th1 Cells/cytology/immunology/*metabolism
PMC - PMC5405198
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Batf3
OT  - CCL5
OT  - CD8alpha(+) DCs
OT  - Th1 cells
EDAT- 2017/04/16 06:00
MHDA- 2018/01/18 06:00
PMCR- 2017/04/06
CRDT- 2017/04/16 06:00
PHST- 2016/10/01 00:00 [received]
PHST- 2017/03/24 00:00 [revised]
PHST- 2017/04/04 00:00 [accepted]
PHST- 2017/04/16 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/04/16 06:00 [entrez]
PHST- 2017/04/06 00:00 [pmc-release]
AID - S2352-3964(17)30151-2 [pii]
AID - 10.1016/j.ebiom.2017.04.008 [doi]
PST - ppublish
SO  - EBioMedicine. 2017 Apr;18:188-198. doi: 10.1016/j.ebiom.2017.04.008. Epub 2017 
      Apr 6.