PMID- 28411501
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20181202
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 114
DP  - 2017 Oct
TI  - Different cross protection scopes of two avian influenza H5N1 vaccines against 
      infection of layer chickens with a heterologous highly pathogenic virus.
PG  - 143-152
LID - S0034-5288(17)30403-4 [pii]
LID - 10.1016/j.rvsc.2017.04.005 [doi]
AB  - Avian influenza (AI) virus strains vary in antigenicity, and antigenic 
      differences between circulating field virus and vaccine virus will affect the 
      effectiveness of vaccination of poultry. Antigenic relatedness can be assessed by 
      measuring serological cross-reactivity using haemagglutination inhibition (HI) 
      tests. Our study aims to determine the relation between antigenic relatedness 
      expressed by the Archetti-Horsfall ratio, and reduction of virus transmission of 
      highly pathogenic H5N1 AI strains among vaccinated layers. Two vaccines were 
      examined, derived from H5N1 AI virus strains A/Ck/WJava/Sukabumi/006/2008 and 
      A/Ck/CJava/Karanganyar/051/2009. Transmission experiments were carried out in 
      four vaccine and two control groups, with six sets of 16 specified pathogen free 
      (SPF) layer chickens. Birds were vaccinated at 4weeks of age with one strain and 
      challenge-infected with the homologous or heterologous strain at 8weeks of age. 
      No transmission or virus shedding occurred in groups challenged with the 
      homologous strain. In the group vaccinated with the Karanganyar strain, high 
      cross-HI responses were observed, and no transmission of the Sukabumi strain 
      occurred. However, in the group vaccinated with the Sukabumi strain, cross-HI 
      titres were low, virus shedding was not reduced, and multiple transmissions to 
      contact birds were observed. This study showed large differences in 
      cross-protection of two vaccines based on two different highly pathogenic H5N1 
      virus strains. This implies that extrapolation of in vitro data to clinical 
      protection and reduction of virus transmission might not be straightforward.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Poetri, Okti Nadia
AU  - Poetri ON
AD  - Faculty of Veterinary Medicine, Department of Animal Diseases and Veterinary 
      Public Health, Bogor Agricultural University, Dramaga, Bogor 16680, West Java, 
      Indonesia. Electronic address: dia_poetri@ipb.ac.id.
FAU - Van Boven, Michiel
AU  - Van Boven M
AD  - Centre for Infectious Disease Control, National Institute for Public Health and 
      the Environment, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The 
      Netherlands.
FAU - Koch, Guus
AU  - Koch G
AD  - Central Veterinary Institute, Wageningen University and Research Centre, Part of 
      Wageningen UR, Houtribweg 39, 8221 RA Lelystad, The Netherlands.
FAU - Stegeman, Arjan
AU  - Stegeman A
AD  - Faculty of Veterinary Medicine, Department of Farm Animal Health, Utrecht 
      University, Yalelaan 7, 3584 CL Utrecht, The Netherlands.
FAU - Claassen, Ivo
AU  - Claassen I
AD  - Central Veterinary Institute, Wageningen University and Research Centre, Part of 
      Wageningen UR, Houtribweg 39, 8221 RA Lelystad, The Netherlands.
FAU - Wayan Wisaksana, I
AU  - Wayan Wisaksana I
AD  - PT Vaksindo Satwa Nusantara, Jl. Mercedes Benz, Cileungsi Kidul, Gunung Putri, 
      Bogor 16964, West Java, Indonesia.
FAU - Bouma, Annemarie
AU  - Bouma A
AD  - Faculty of Veterinary Medicine, Department of Farm Animal Health, Utrecht 
      University, Yalelaan 7, 3584 CL Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170408
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Animals
MH  - Chickens/*immunology
MH  - Cross Protection
MH  - Hemagglutination Inhibition Tests
MH  - Influenza A Virus, H5N1 Subtype/*immunology
MH  - Influenza Vaccines/*immunology
MH  - Influenza in Birds/*prevention & control
MH  - Specific Pathogen-Free Organisms
MH  - Vaccination/veterinary
MH  - Virus Shedding
OTO - NOTNLM
OT  - Archetti-Horsfall ratio
OT  - Avian influenza
OT  - Cross protection
OT  - H5N1
EDAT- 2017/04/16 06:00
MHDA- 2018/04/17 06:00
CRDT- 2017/04/16 06:00
PHST- 2016/02/15 00:00 [received]
PHST- 2017/04/06 00:00 [revised]
PHST- 2017/04/07 00:00 [accepted]
PHST- 2017/04/16 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2017/04/16 06:00 [entrez]
AID - S0034-5288(17)30403-4 [pii]
AID - 10.1016/j.rvsc.2017.04.005 [doi]
PST - ppublish
SO  - Res Vet Sci. 2017 Oct;114:143-152. doi: 10.1016/j.rvsc.2017.04.005. Epub 2017 Apr 
      8.