PMID- 28412461
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20220330
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 120
DP  - 2017 Jun
TI  - Effects of low-dose aspirin on maternal blood pressure and vascular function in 
      an experimental model of gestational hypertension.
PG  - 267-278
LID - S1043-6618(16)31108-2 [pii]
LID - 10.1016/j.phrs.2017.04.012 [doi]
AB  - Daily intake of low-dose aspirin after 12weeks of gestation is currently 
      recommended as a preventative intervention in pregnancies in high risk of 
      developing preeclampsia. This recommendation is based on epidemiological 
      evidence, whereas experimental studies investigating the exact mechanisms of 
      aspirin action during pregnancy are lacking. We previously showed that treating 
      pregnant rats with a synthetic mimetic of unmethylated CpG DNA (bacterial DNA) 
      caused preeclampsia-like characteristics such as maternal hypertension and 
      increased cyclooxygenase (COX) expression and activity. In this study, we tested 
      the hypothesis that daily maternal treatment with low-dose aspirin would prevent 
      the development of maternal hypertension, reduce COX activity and thromboxane 
      A(2) (TxA(2)) production, and improve maternal vascular function in pregnant rats 
      exposed to CpG ODN during gestation. Pregnant rats were treated with ODN2395 
      (synthetic CpG DNA) or saline (vehicle) on gestational days (GD) 14, 16, 18. 
      Daily low-dose aspirin treatment (1.5mg/kgBW) started on GD10 and continued 
      throughout gestation. Pregnant rats treated with ODN2395 had greater systolic 
      blood pressure compared to controls (120+/-4mmHg vs. 100+/-5mmHg, p=0.03) and aspirin 
      did not prevent this increase (p=0.86). Aspirin prevented ODN2395-induced 
      increases of TxB(2) (TxA(2) metabolite) in serum and mesenteric arteries. ODN2395 
      increased expression of COX-1 and COX-2 in mesenteric and uterine arteries and 
      aspirin abolished these effects. Aspirin reduced contractile responses to 
      phenylephrine and U46619 (TxA(2) mimetic) in mesenteric arteries from control 
      rats but not from ODN2395-treated rats. In conclusion, treatment with low-dose 
      aspirin reduced systemic and vascular COX expression and activity but did not 
      prevent the development of maternal hypertension induced by exposure to 
      unmethylated CpG DNA (bacterial DNA).
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Osikoya, Oluwatobiloba
AU  - Osikoya O
AD  - Institute for Cardiovascular and Metabolic Disease, University of North Texas 
      Health Science Center, Fort Worth, TX, USA.
FAU - Jaini, Paresh A
AU  - Jaini PA
AD  - Institute for Cardiovascular and Metabolic Disease, University of North Texas 
      Health Science Center, Fort Worth, TX, USA.
FAU - Nguyen, An
AU  - Nguyen A
AD  - Institute for Cardiovascular and Metabolic Disease, University of North Texas 
      Health Science Center, Fort Worth, TX, USA.
FAU - Valdes, Melissa
AU  - Valdes M
AD  - Institute for Cardiovascular and Metabolic Disease, University of North Texas 
      Health Science Center, Fort Worth, TX, USA.
FAU - Goulopoulou, Styliani
AU  - Goulopoulou S
AD  - Institute for Cardiovascular and Metabolic Disease, University of North Texas 
      Health Science Center, Fort Worth, TX, USA. Electronic address: 
      styliani.goulopoulou@unthsc.edu.
LA  - eng
PT  - Journal Article
DEP - 20170412
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 57576-52-0 (Thromboxane A2)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Animals
MH  - Aspirin/administration & dosage/*therapeutic use
MH  - Blood Pressure/*drug effects
MH  - Cyclooxygenase Inhibitors/administration & dosage/*therapeutic use
MH  - Disease Models, Animal
MH  - Female
MH  - Hypertension, Pregnancy-Induced/metabolism/physiopathology/*prevention & control
MH  - Mesenteric Arteries/drug effects/metabolism/physiopathology
MH  - Pregnancy
MH  - Prostaglandin-Endoperoxide Synthases/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thromboxane A2/metabolism
OTO - NOTNLM
OT  - Cyclooxygenase
OT  - Preeclampsia
OT  - Pregnancy
OT  - Thromboxane
OT  - Toll-like receptors
OT  - Vascular function
EDAT- 2017/04/17 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/04/17 06:00
PHST- 2016/10/23 00:00 [received]
PHST- 2017/03/01 00:00 [revised]
PHST- 2017/04/10 00:00 [accepted]
PHST- 2017/04/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/04/17 06:00 [entrez]
AID - S1043-6618(16)31108-2 [pii]
AID - 10.1016/j.phrs.2017.04.012 [doi]
PST - ppublish
SO  - Pharmacol Res. 2017 Jun;120:267-278. doi: 10.1016/j.phrs.2017.04.012. Epub 2017 
      Apr 12.