PMID- 28413317
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1226-8453 (Print)
IS  - 2093-4947 (Electronic)
IS  - 1226-8453 (Linking)
VI  - 41
IP  - 2
DP  - 2017 Apr
TI  - Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing 
      expression of proinflammatory cytokines and chemokines in vivo and in vitro.
PG  - 134-143
LID - 10.1016/j.jgr.2016.02.003 [doi]
AB  - BACKGROUND: The prevalence of allergic inflammatory diseases such as atopic 
      dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and 
      complete recovery is difficult. Korean Red Ginseng, which is the heat-processed 
      root of Panax ginseng Meyer, is widely and frequently used as a traditional 
      medicine in East Asia. In this study, we investigated whether Korean Red Ginseng 
      water extract (RGE) regulates the expression of proinflammatory cytokines and 
      chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa 
      B (NF-kappaB) pathway in allergic inflammation. METHODS: Compound 48/80-induced 
      anaphylactic shock and 1-fluoro-2,4-dinitrobenzene (DNFB)-induced AD-like skin 
      lesion mice models were used to investigate the antiallergic effects of RGE. 
      Human keratinocytes (HaCaT cells) and human mast cells (HMC-1) were also used to 
      clarify the effects of RGE on the expression of proinflammatory cytokines and 
      chemokines. RESULTS: Anaphylactic shock and DNFB-induced AD-like skin lesions 
      were attenuated by RGE administration through reduction of serum immunoglobulin E 
      (IgE) and interleukin (IL)-6 levels in mouse models. RGE also reduced the 
      production of proinflammatory cytokines including IL-1beta, IL-6, and IL-8, and 
      expression of chemokines such as IL-8, thymus and activation-regulated chemokine 
      (TARC), and macrophage-derived chemokine (MDC) in HaCaT cells. Additionally, RGE 
      decreased the release of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-6, and IL-8 
      as well as expressions of chemokines including macrophage inflammatory protein 
      (MIP)-1alpha, MIP-1beta, regulated on activation, normal T cell expressed and secreted 
      (RANTES), monocyte chemoattractant protein (MCP)-1, and IL-8 in HMC-1 cells. 
      Furthermore, our data demonstrated that these inhibitory effects occurred through 
      blockage of the MAPK and NF-kappaB pathway. CONCLUSION: RGE may be a useful 
      therapeutic agent for the treatment of allergic inflammatory diseases such as 
      AD-like dermatitis.
FAU - Kee, Ji-Ye
AU  - Kee JY
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines 
      Research Institute, Wonkwang University, Iksan, Korea.
FAU - Jeon, Yong-Deok
AU  - Jeon YD
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines 
      Research Institute, Wonkwang University, Iksan, Korea.
AD  - Department of Oriental Medicine Resources, College of Environmental and 
      Bioresources Sciences, Chonbuk National University, Iksan-si, Jeollabuk-do, 
      Korea.
FAU - Kim, Dae-Seung
AU  - Kim DS
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines 
      Research Institute, Wonkwang University, Iksan, Korea.
FAU - Han, Yo-Han
AU  - Han YH
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines 
      Research Institute, Wonkwang University, Iksan, Korea.
FAU - Park, Jinbong
AU  - Park J
AD  - College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 
      Seoul, Korea.
FAU - Youn, Dong-Hyun
AU  - Youn DH
AD  - College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 
      Seoul, Korea.
FAU - Kim, Su-Jin
AU  - Kim SJ
AD  - Department of Cosmeceutical Science, Daegu Hanny University, Gyeongsan-si, Korea.
FAU - Ahn, Kwang Seok
AU  - Ahn KS
AD  - College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 
      Seoul, Korea.
FAU - Um, Jae-Young
AU  - Um JY
AD  - College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 
      Seoul, Korea.
FAU - Hong, Seung-Heon
AU  - Hong SH
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines 
      Research Institute, Wonkwang University, Iksan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160219
PL  - Korea (South)
TA  - J Ginseng Res
JT  - Journal of ginseng research
JID - 100890690
PMC - PMC5386127
OTO - NOTNLM
OT  - Korean Red Ginseng
OT  - allergic inflammation
OT  - chemokine
OT  - keratinocytes
OT  - mast cells
EDAT- 2017/04/18 06:00
MHDA- 2017/04/18 06:01
PMCR- 2016/02/19
CRDT- 2017/04/18 06:00
PHST- 2015/10/14 00:00 [received]
PHST- 2016/01/29 00:00 [revised]
PHST- 2016/02/09 00:00 [accepted]
PHST- 2017/04/18 06:00 [entrez]
PHST- 2017/04/18 06:00 [pubmed]
PHST- 2017/04/18 06:01 [medline]
PHST- 2016/02/19 00:00 [pmc-release]
AID - S1226-8453(16)00009-9 [pii]
AID - 10.1016/j.jgr.2016.02.003 [doi]
PST - ppublish
SO  - J Ginseng Res. 2017 Apr;41(2):134-143. doi: 10.1016/j.jgr.2016.02.003. Epub 2016 
      Feb 19.