PMID- 28413686
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210109
IS  - 2051-3380 (Print)
IS  - 2051-3380 (Electronic)
IS  - 2051-3380 (Linking)
VI  - 5
IP  - 4
DP  - 2017 Jul
TI  - Cytokine profiles of amyopathic dermatomyositis with interstitial lung diseases 
      treated with mycophenolate.
PG  - e00235
LID - 10.1002/rcr2.235 [doi]
LID - e00235
AB  - A 59-year-old Japanese man diagnosed with interstitial lung disease associated 
      with amyopathic dermatomyositis with anti-melanoma differentiation-associated 
      gene 5 (MDA-5) antibodies was treated with intravenous methyl prednisolone (PSL) 
      1000 mg, oral PSL 1 mg/kg, and oral cyclosporin 200 mg daily. His respiratory 
      condition worsened after treatment with two times of intravenous cyclophosphamide 
      and another steroid pulse therapy as well as PSL and cyclosporin. Addition of 
      mycophenolate mofetil (MMF), 1.5 g daily improved PaO(2)/FiO(2) (PF) ratio of the 
      patient from 294 to 360 at 4 weeks and 416 at 15 weeks after addition of MMF. We 
      measured cytokine concentration in preserved serum taken at 11 and 7 weeks before 
      addition of MMF and at 4, 11, and 15 weeks after MMF administration. Of the 28 
      cytokines evaluated, the concentrations of fibroblast growth factors-2 (FGF-2), 
      chemokine (C-X3-C motif) ligand 1 (CX3CL1), interleukin (IL)-1ra, IL-17A, 
      inducible protein 10 (IP-10), and monocyte chemotactic protein-1 (MCP-1) 
      decreased after addition of MMF. These results suggest that MMF may be beneficial 
      to patients with interstitial lung disease by modification of the cytokine/growth 
      factor protein expression.
FAU - Hayashi, Masachika
AU  - Hayashi M
AD  - Division of Respiratory Medicine Niigata University Medical and Dental Hospital 
      Niigata Japan.
FAU - Aoki, Ami
AU  - Aoki A
AD  - Division of Respiratory Medicine Niigata University Medical and Dental Hospital 
      Niigata Japan.
FAU - Asakawa, Katsuaki
AU  - Asakawa K
AD  - Division of Respiratory Medicine Niigata University Medical and Dental Hospital 
      Niigata Japan.
FAU - Sakagami, Takuro
AU  - Sakagami T
AD  - Division of Respiratory Medicine Niigata University Medical and Dental Hospital 
      Niigata Japan.
FAU - Kikuchi, Toshiaki
AU  - Kikuchi T
AD  - Division of Respiratory Medicine Niigata University Medical and Dental Hospital 
      Niigata Japan.
FAU - Takada, Toshinori
AU  - Takada T
AUID- ORCID: 0000-0001-5887-8375
AD  - Division of Respiratory Medicine Niigata University Medical and Dental Hospital 
      Niigata Japan.
AD  - Uonuma Institute of Community Medicine Niigata University Medical and Dental 
      Hospital Minami-uonuma Japan.
LA  - eng
PT  - Case Reports
DEP - 20170411
PL  - United States
TA  - Respirol Case Rep
JT  - Respirology case reports
JID - 101631052
PMC - PMC5387408
OTO - NOTNLM
OT  - Anti-melanoma differentiation-associated gene 5 antibody
OT  - cytokine
OT  - dermatomyositis
OT  - interstitial lung disease
OT  - mycophenolate mofetil
EDAT- 2017/04/18 06:00
MHDA- 2017/04/18 06:01
PMCR- 2017/04/11
CRDT- 2017/04/18 06:00
PHST- 2017/01/11 00:00 [received]
PHST- 2017/03/14 00:00 [revised]
PHST- 2017/03/20 00:00 [accepted]
PHST- 2017/04/18 06:00 [entrez]
PHST- 2017/04/18 06:00 [pubmed]
PHST- 2017/04/18 06:01 [medline]
PHST- 2017/04/11 00:00 [pmc-release]
AID - RCR2235 [pii]
AID - 10.1002/rcr2.235 [doi]
PST - epublish
SO  - Respirol Case Rep. 2017 Apr 11;5(4):e00235. doi: 10.1002/rcr2.235. eCollection 
      2017 Jul.