PMID- 28413930
OWN - NLM
STAT- MEDLINE
DCOM- 20170529
LR  - 20190126
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Print)
IS  - 1099-8004 (Linking)
VI  - 19
IP  - 3
DP  - 2017 May
TI  - Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in 
      Children.
PG  - 339-349
LID - 10.1177/1099800417692878 [doi]
AB  - OBJECTIVE: This study used a candidate gene approach to examine genomic variation 
      associated with pain, anxiety, and distress in children undergoing a medical 
      procedure. STUDY DESIGN: Children aged 4-10 years having an IV catheter insertion 
      were recruited from three Midwestern children's hospitals. Self-report measures 
      of pain, anxiety, and distress were obtained as well as an observed measure of 
      distress. Samples were collected from children and biological parents for 
      analysis of genomic variation. Genotyped variants had known or suspected 
      association with phenotypes of interest. Analyses included child-only association 
      and family-based transmission disequilibrium tests. RESULTS: Genotype and 
      phenotype data were available from 828 children and 376 family trios. Children 
      were 50% male, had a mean age of 7.2 years, and were 84% White/non-Hispanic. In 
      family-based analysis, one single-nucleotide polymorphism (SNP; rs1143629, 
      interleukin ( IL1B) 1beta) was associated with observed child distress at 
      Bonferroni-corrected levels of significance ( p = .00013), while two approached 
      significance for association with high state anxiety (rs6330 Nerve Growth Factor, 
      Beta Subunit, [ NGFB]) and high trait anxiety (rs6265 brain-derived neurotrophic 
      factor [ BDNF]). In the child-only analysis, multiple SNPs showed nominal 
      evidence of relationships with phenotypes of interest. rs6265 BDNF and rs2941026 
      cholecystokinin B receptor had possible relationships with trait anxiety in 
      child-only and family-based analyses. CONCLUSIONS: Exploring genomic variation 
      furthers our understanding of pain, anxiety, and distress and facilitates genomic 
      screening to identify children at high risk of procedural pain, anxiety, and 
      distress. Combined with clinical observations and knowledge, such explorations 
      could help guide tailoring of interventions to limit procedure-related distress 
      and identify genes and pathways of interest for future genotype-phenotype 
      studies.
FAU - Ersig, Anne L
AU  - Ersig AL
AD  - 1 College of Nursing, The University of Iowa, Iowa City, IA, USA.
FAU - Schutte, Debra L
AU  - Schutte DL
AD  - 2 College of Nursing, Wayne State University, Detroit, MI, USA.
FAU - Standley, Jennifer
AU  - Standley J
AD  - 3 College of Medicine, The University of Iowa, Iowa City, IA, USA.
FAU - Leslie, Elizabeth
AU  - Leslie E
AD  - 4 School of Dental Medicine, The University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Zimmerman, Bridget
AU  - Zimmerman B
AD  - 5 College of Public Health, The University of Iowa, Iowa City, IA, USA.
FAU - Kleiber, Charmaine
AU  - Kleiber C
AD  - 6 The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
FAU - Hanrahan, Kirsten
AU  - Hanrahan K
AD  - 6 The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
FAU - Murray, Jeffrey C
AU  - Murray JC
AD  - 3 College of Medicine, The University of Iowa, Iowa City, IA, USA.
FAU - McCarthy, Ann Marie
AU  - McCarthy AM
AD  - 1 College of Nursing, The University of Iowa, Iowa City, IA, USA.
LA  - eng
GR  - R01 NR005269/NR/NINR NIH HHS/United States
GR  - U54 TR001013/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20170313
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Anxiety/genetics
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Catheterization, Peripheral/*adverse effects/psychology
MH  - Child
MH  - Child, Hospitalized/*psychology
MH  - Depression/genetics
MH  - Female
MH  - *Genetic Variation
MH  - Humans
MH  - Male
MH  - Pain/genetics
MH  - Phenotype
PMC - PMC5609488
MID - NIHMS905000
OTO - NOTNLM
OT  - anxiety
OT  - children
OT  - distress
OT  - genetics
OT  - procedural pain
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2017/04/18 06:00
MHDA- 2017/05/30 06:00
PMCR- 2018/05/01
CRDT- 2017/04/18 06:00
PHST- 2017/04/18 06:00 [entrez]
PHST- 2017/04/18 06:00 [pubmed]
PHST- 2017/05/30 06:00 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - 10.1177_1099800417692878 [pii]
AID - 10.1177/1099800417692878 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2017 May;19(3):339-349. doi: 10.1177/1099800417692878. Epub 2017 
      Mar 13.