PMID- 28413981
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180923
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 14
IP  - 11
DP  - 2017
TI  - Default Mode Network Connectivity and Related White Matter Disruption in Type 2 
      Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment.
PG  - 1238-1246
LID - 10.2174/1567205014666170417113441 [doi]
AB  - BACKGROUND: As a risk factor for Alzheimer's disease (AD), type 2 diabetes 
      mellitus (T2DM) itself causes cognitive impairment and has higher prevalence of 
      mild cognitive impairment (MCI). OBJECTIVE: The aim of this study was to explore 
      the cognition especially the episodic memory difference, the DMN functional 
      connectivity and DMN-related white matter integrity in patients with both T2DM 
      and amnestic MCI (T2DM-MCI) as compared to patients with T2DM only. METHODS: 
      Focusing especially on T2DM population, we investigated the default mode network 
      (DMN) through resting-state functional magnetic resonance imaging among 22 
      elderly T2DM-MCI patients and 24 elderly T2DM patients. Including primarily the 
      bilateral cingulum, hippocampus and uncinate fasciculus, these DMN white matter 
      fibers were also closely associated with episodic memory and the integrity of 
      them was also investigated using diffusion tensor imaging in 19 elderly T2DM-MCI 
      patients and 23 elderly T2DM patients. RESULTS: Compared with the patients with 
      T2DM, the T2DM-MCI patients performed worse in several areas of cognition besides 
      episodic memory, and showed stronger DMN functional connectivity in the left 
      precuneus and weaker functional connectivity in the left calcarine, as well as 
      decreased integrity of the left cingulate bundle and bilateral uncinate 
      fasciculus. Furthermore, a correlation analysis indicated that higher left 
      calcarine connectivity was associated with better episodic memory performance 
      among the overall group. CONCLUSION: Our results demonstrated that T2DM patients 
      with comorbid amnestic MCI had abnormal functional connectivity patterns and 
      decreased white matter integrity, which could potentially serve as AD or AD risk 
      biomarkers for early detection of those elderly individuals with T2DM.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Qi, Di
AU  - Qi D
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing 100875. China.
FAU - Wang, Ailin
AU  - Wang A
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing 100875. China.
FAU - Chen, Yaojing
AU  - Chen Y
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing 100875. China.
FAU - Chen, Kewei
AU  - Chen K
AD  - Banner Alzheimer's Institute, Phoenix, AZ 85006. United States.
FAU - Zhang, Sisi
AU  - Zhang S
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing 100875. China.
FAU - Zhang, Junying
AU  - Zhang J
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing 100875. China.
FAU - Li, Xin
AU  - Li X
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing 100875. China.
FAU - Ai, Lin
AU  - Ai L
AD  - Department of Radiology, Beijing Tiantan Hospital, Beijing Neurosurgery 
      Institute, Capital Medical University, Beijing 100050. China.
FAU - Zhang, Zhanjun
AU  - Zhang Z
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing 100875. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
SB  - IM
MH  - Aged
MH  - Brain/*diagnostic imaging/pathology/*physiopathology
MH  - Brain Mapping
MH  - Cognitive Dysfunction/complications/*diagnostic 
      imaging/pathology/*physiopathology
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*diagnostic 
      imaging/pathology/*physiopathology
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Episodic
MH  - Middle Aged
MH  - Neural Pathways/diagnostic imaging/pathology/physiopathology
MH  - Neuropsychological Tests
MH  - Rest
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - default mode network
OT  - episodic memory
OT  - functional connectivity
OT  - mild cognitive impairment
OT  - white matter integrity
EDAT- 2017/04/18 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/04/18 06:00
PHST- 2017/01/08 00:00 [received]
PHST- 2017/04/01 00:00 [revised]
PHST- 2017/04/11 00:00 [accepted]
PHST- 2017/04/18 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/04/18 06:00 [entrez]
AID - CAR-EPUB-82860 [pii]
AID - 10.2174/1567205014666170417113441 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2017;14(11):1238-1246. doi: 
      10.2174/1567205014666170417113441.