PMID- 28414034
OWN - NLM
STAT- MEDLINE
DCOM- 20180322
LR  - 20181005
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1665
DP  - 2017 Jun 15
TI  - Age exacerbates surgery-induced cognitive impairment and neuroinflammation in 
      Sprague-Dawley rats: the role of IL-4.
PG  - 65-73
LID - S0006-8993(17)30158-0 [pii]
LID - 10.1016/j.brainres.2017.04.004 [doi]
AB  - Age is the most prominent risk factor for the development of postoperative 
      cognitive dysfunction. This study investigated the potential role of 
      anti-inflammatory interleukin (IL)-4 in age-related differences of 
      surgery-induced cognitive deficits and neuroinflammatory responses. Both adult 
      and aged Sprague-Dawley male rats were subjected to partial hepatectomy or 
      partial hepatectomy with a cisterna magna infusion of IL-4. On postoperative days 
      1, 3, and 7, the rats were subjected to a reversed Morris water maze test. 
      Hippocampal IL-1beta, IL-6, IL-4, and IL-4 receptor (IL-4R) were measured at each 
      time point. Brain derived neurotrophic factor (BDNF), synaptophysin, Ionized 
      calcium-binding adapter molecule 1 (Iba-1), microglial M2 phenotype marker Arg1, 
      and CD200 were also examined in the hippocampus. Age induced an exacerbated 
      cognitive impairment and an amplified neuroinflammatory response triggered by 
      surgical stress on postoperative days 1 and 3. A corresponding decline in the 
      anti-inflammatory cytokine IL-4 and BDNF were also found in the aged rats at the 
      same time point. Treatment with IL-4 downregulated the expression of 
      proinflammatory cytokines (e.g., IL-1beta and IL-6), increased the levels of BDNF 
      and synaptophysin in the brain and improved the behavioral performance. An 
      increased Arg1 expression and a high level of CD200 were also observed after a 
      cisterna magna infusion of IL-4. An age-related decrease in IL-4 expression 
      exacerbated surgery-induced cognitive deficits and exaggerated the 
      neuroinflammatory responses. Treatment with IL-4 potentially attenuated these 
      effects by enhancing BDNF and synaptophysin expression, inhibiting microglia 
      activation and decreasing the associated production of proinflammatory cytokines.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Li, Zhe
AU  - Li Z
AD  - Department of Anesthesiology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China. Electronic address: jllizhe@126.com.
FAU - Liu, Fang
AU  - Liu F
AD  - Department of Neurology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China. Electronic address: liufang219@163.com.
FAU - Ma, Hong
AU  - Ma H
AD  - Department of Anesthesiology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China. Electronic address: cmumh2016@gmail.com.
FAU - White, Paul F
AU  - White PF
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 
      White Mountain Institute, The Sea Ranch, CA, USA. Electronic address: 
      whitemountaininstitute@hotmail.com.
FAU - Yumul, Roya
AU  - Yumul R
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 
      Electronic address: Roya.Yumul@cshs.org.
FAU - Jiang, Yanhua
AU  - Jiang Y
AD  - Department of Anesthesiology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China. Electronic address: 13840152025@163.com.
FAU - Wang, Na
AU  - Wang N
AD  - Department of Anesthesiology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China. Electronic address: wangna19880229@126.com.
FAU - Cao, Xuezhao
AU  - Cao X
AD  - Department of Anesthesiology, The First Hospital of China Medical University, 
      Shenyang, Liaoning, China. Electronic address: xuezhaocao2011@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170414
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Cognitive Dysfunction/metabolism/*physiopathology
MH  - Disease Models, Animal
MH  - Hippocampus/metabolism/*surgery
MH  - Inflammation/*physiopathology
MH  - Interleukin-4/*metabolism
MH  - Microglia/metabolism
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Aging
OT  - Cytokines
OT  - Hippocampus
OT  - Neuroinflammation
OT  - Postoperative cognitive dysfunction (POCD)
EDAT- 2017/04/18 06:00
MHDA- 2018/03/23 06:00
CRDT- 2017/04/18 06:00
PHST- 2016/12/24 00:00 [received]
PHST- 2017/03/31 00:00 [revised]
PHST- 2017/04/10 00:00 [accepted]
PHST- 2017/04/18 06:00 [pubmed]
PHST- 2018/03/23 06:00 [medline]
PHST- 2017/04/18 06:00 [entrez]
AID - S0006-8993(17)30158-0 [pii]
AID - 10.1016/j.brainres.2017.04.004 [doi]
PST - ppublish
SO  - Brain Res. 2017 Jun 15;1665:65-73. doi: 10.1016/j.brainres.2017.04.004. Epub 2017 
      Apr 14.