PMID- 28415406
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20170724
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 75
DP  - 2017 Jun 1
TI  - PCL foamed scaffolds loaded with 5-fluorouracil anti-cancer drug prepared by an 
      eco-friendly route.
PG  - 1191-1197
LID - S0928-4931(16)31695-2 [pii]
LID - 10.1016/j.msec.2017.03.011 [doi]
AB  - This study describes a new preparation method, which combines freeze drying and 
      supercritical CO(2) foaming approaches, for the preparation of drug delivery 
      scaffolds of polycaprolactone loaded with 5-fluorouracil, an anti-cancer drug, 
      with low solubility in scCO(2). It is a principal objective of this work to 
      design a scCO(2) strategy to reduce 5-Fu solubility limitations in its 
      homogeneous distribution into a PCL scaffold through the design of an innovative 
      processing method. The design of this process is considered valuable for the 
      development of clean technology in pharmacy and medicine, since most of the 
      active agents have a null solubility in scCO(2).Supercritical CO(2) is used as a 
      blowing agent to induce polymer foaming by means of the low temperature pressure 
      quench process. The resulting samples have been prepared under different 
      operational conditions focused on enhancing the performance of the release 
      process. In this case, design of experiments (DOE) was considered for a more 
      comprehensive and systematic optimization of the product. In particular, drug 
      amount, equals to 4.8 or 9.1wt%, process temperature, of 45 or 50 degrees C and 
      depressurization rate, equals to 0.1MPas(-1) or 2MPas(-1) were selected as the 
      factors to be investigated by a three-factor at two-level full factorial design. 
      Samples were characterized to establish porosity data, drug loading percentage 
      and, especially, release profile chromatographically monitored. Results from DOE 
      have concluded which are the best samples providing a sustained drug release for 
      several days, which may be of great interest to develop materials for tissue 
      engineering and sustained release applications.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Salerno, Aurelio
AU  - Salerno A
AD  - Institut de Ciencia de Materials de Barcelona (CSIC), Campus de la UAB, 08193 
      Bellaterra, Spain; Centre for Advanced Biomaterials for Health Care, Istituto 
      Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli, Italy. 
      Electronic address: asalerno@unina.it.
FAU - Domingo, Concepcion
AU  - Domingo C
AD  - Institut de Ciencia de Materials de Barcelona (CSIC), Campus de la UAB, 08193 
      Bellaterra, Spain. Electronic address: conchi@icmab.es.
FAU - Saurina, Javier
AU  - Saurina J
AD  - Department of Analytical Chemistry, University of Barcelona, Marti i Franques 
      1-11, 08028 Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Polyesters)
RN  - 24980-41-4 (polycaprolactone)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - *Antineoplastic Agents/chemistry/pharmacokinetics/pharmacology
MH  - *Drug Carriers/chemical synthesis/chemistry/pharmacokinetics/pharmacology
MH  - *Fluorouracil/chemistry/pharmacokinetics/pharmacology
MH  - *Polyesters/chemistry/pharmacokinetics/pharmacology
OTO - NOTNLM
OT  - 5-Fluoracilo
OT  - Drug delivery
OT  - Polycaprolactone
OT  - Scaffolds
OT  - Supercritical CO(2)
EDAT- 2017/04/19 06:00
MHDA- 2017/07/25 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/10/10 00:00 [received]
PHST- 2017/02/06 00:00 [revised]
PHST- 2017/03/02 00:00 [accepted]
PHST- 2017/04/19 06:00 [entrez]
PHST- 2017/04/19 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
AID - S0928-4931(16)31695-2 [pii]
AID - 10.1016/j.msec.2017.03.011 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:1191-1197. doi: 
      10.1016/j.msec.2017.03.011. Epub 2017 Mar 6.