PMID- 28415485
OWN - NLM
STAT- MEDLINE
DCOM- 20170731
LR  - 20170731
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 75
DP  - 2017 Jun 1
TI  - Antimicrobial activity of eumelanin-based hybrids: The role of TiO(2) in 
      modulating the structure and biological performance.
PG  - 454-462
LID - S0928-4931(16)32197-X [pii]
LID - 10.1016/j.msec.2016.12.135 [doi]
AB  - Eco-friendly hybrid Eumelanin-TiO(2) nanostructures, recently obtained through in 
      situ methodology based on hydrothermal route, have shown a striking antimicrobial 
      activity, after exposure to oxidative environment, even under visible light 
      induction condition. Nevertheless, the role of each component in defining the 
      efficacy of these biological properties is far from being clearly defined. 
      Furthermore, the effect of oxidative step on hybrids structure has not yet 
      addressed. This study aims at elucidating the role of the ratio between eumelanin 
      precursor, 5,6-dihydroxyindole-2-carboxylic acid (DHICA), and TiO(2), for its 
      polymerization in defining morphology and structural organization of 
      TiO(2)-melanin nanostructures. Furthermore, tests on a Gram-negative Escherichia 
      coli DH5alpha strain under UV irradiation and even visible light allowed to assess 
      the contribution of each component, as well as of the TiO(2)-DHICA charge 
      transfer complex to overall biological performance. Finally, results of biocide 
      characterization were combined with spectroscopic evidences to prove that 
      oxidative treatment induces a marked structural modification in melanin thus 
      enhancing overall antimicrobial efficacy.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Vitiello, Giuseppe
AU  - Vitiello G
AD  - Department of Chemical, Materials and Production Engineering, University of 
      Naples "Federico II", p.le V. Tecchio 80, 80125 Naples, Italy; CSGI, Consorzio 
      Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Via della 
      Lastruccia 3, 50019 Florence, Italy.
FAU - Pezzella, Alessandro
AU  - Pezzella A
AD  - Department of Chemical Sciences, University of Naples "Federico II" via Cintia 4, 
      80126 Naples, Italy; Institute for Polymers, Composites and Biomaterials (IPCB), 
      CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Na), Italy.
FAU - Zanfardino, Anna
AU  - Zanfardino A
AD  - Department of Biology, University of Naples "Federico II" via Cintia 4, 80126 
      Naples, Italy.
FAU - Silvestri, Brigida
AU  - Silvestri B
AD  - Department of Chemical, Materials and Production Engineering, University of 
      Naples "Federico II", p.le V. Tecchio 80, 80125 Naples, Italy.
FAU - Giudicianni, Paola
AU  - Giudicianni P
AD  - Istituto di Ricerche sulla Combustione, Centro Nazionale delle Ricerche IRC-CNR, 
      via Claudio, 80125 Napoli, Italy.
FAU - Costantini, Aniello
AU  - Costantini A
AD  - Department of Chemical, Materials and Production Engineering, University of 
      Naples "Federico II", p.le V. Tecchio 80, 80125 Naples, Italy.
FAU - Varcamonti, Mario
AU  - Varcamonti M
AD  - Department of Biology, University of Naples "Federico II" via Cintia 4, 80126 
      Naples, Italy.
FAU - Branda, Francesco
AU  - Branda F
AD  - Department of Chemical, Materials and Production Engineering, University of 
      Naples "Federico II", p.le V. Tecchio 80, 80125 Naples, Italy.
FAU - Luciani, Giuseppina
AU  - Luciani G
AD  - Department of Chemical, Materials and Production Engineering, University of 
      Naples "Federico II", p.le V. Tecchio 80, 80125 Naples, Italy. Electronic 
      address: giuseppina.luciani@unina.it.
LA  - eng
PT  - Journal Article
DEP - 20170212
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Melanins)
RN  - 12627-86-0 (eumelanin)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Anti-Infective Agents/chemistry/pharmacology
MH  - Escherichia coli/*growth & development
MH  - *Melanins/chemistry/pharmacology
MH  - *Titanium/chemistry/pharmacology
OTO - NOTNLM
OT  - Antimicrobial
OT  - DHICA
OT  - Eumelanin
OT  - LMCTC
OT  - Nanoparticles
OT  - TiO(2)
EDAT- 2017/04/19 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/11/16 00:00 [received]
PHST- 2016/12/16 00:00 [revised]
PHST- 2016/12/20 00:00 [accepted]
PHST- 2017/04/19 06:00 [entrez]
PHST- 2017/04/19 06:00 [pubmed]
PHST- 2017/08/02 06:00 [medline]
AID - S0928-4931(16)32197-X [pii]
AID - 10.1016/j.msec.2016.12.135 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:454-462. doi: 
      10.1016/j.msec.2016.12.135. Epub 2017 Feb 12.