PMID- 28416249
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20181202
IS  - 2212-1692 (Electronic)
IS  - 1875-9572 (Linking)
VI  - 58
IP  - 5
DP  - 2017 Oct
TI  - Prognostic accuracy of clinical signs and diagnostic tests in cow's milk allergy 
      in newborns.
PG  - 449-454
LID - S1875-9572(17)30174-2 [pii]
LID - 10.1016/j.pedneo.2016.09.009 [doi]
AB  - BACKGROUND: The aim of the study was to explore the correlation between clinical 
      signs and confirmatory tests for cow's milk allergy (CMA) in the neonatal period 
      and their relation to family history and the occurrence of food allergies in the 
      postneonatal period. METHODS: The medical documentation of 361 newborns with 
      suspected CMA and exclusion of other comorbidities was analyzed. The correlations 
      between clinical signs and methods to confirm CMA [elevated levels of total 
      immunoglobulin E (IgE) and/or specific IgE for cow's milk, improvement after the 
      introduction of a cow's milk-free diet and positive challenge procedure] were 
      studied. In 90 children, the data were additionally analyzed in relation to 
      outcome (at the age of 1-11 years), evaluated by questionnaires, which inquired 
      about signs and symptoms of food allergy, methods of CMA confirmation, and the 
      presence of other food allergies. RESULTS: There was a positive correlation 
      between exanthema and confirmed CMA in the neonatal period (R = 0.184; 
      p = <0.001; n = 361), and hematochezia and confirmed CMA in the neonatal 
      (R = 0.203; p < 0.001; n = 361) and postneonatal period (R = 0.215; p = 0.042; 
      n = 90). Additional food allergies in the postneonatal period were positively 
      correlated with neonatal CMA (R = 0.275; p = 0.009; n = 90). No correlation was 
      found between a positive family history of food allergies and CMA in the neonatal 
      (R = -0.66; p = 0.398; n = 165) and postneonatal periods (R = 0.00; p = 1.000; 
      n = 116). CONCLUSION: Neonatal exanthema and hematochezia were the predominant 
      clinical signs in neonates with CMA. Allergies to other food allergens appeared 
      more frequently in children with CMA in the neonatal period. Neonatal CMA did not 
      occur more frequently in families with food allergies.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Nosan, Gregor
AU  - Nosan G
AD  - Division of Pediatrics, Department of Neonatology, University Medical Centre 
      Ljubljana, Ljubljana, Slovenia.
FAU - Jakic, Maja
AU  - Jakic M
AD  - Division of Pediatrics, Department of Neonatology, University Medical Centre 
      Ljubljana, Ljubljana, Slovenia.
FAU - Jager, Miha
AU  - Jager M
AD  - Division of Pediatrics, Department of Neonatology, University Medical Centre 
      Ljubljana, Ljubljana, Slovenia.
FAU - Paro-Panjan, Darja
AU  - Paro-Panjan D
AD  - Division of Pediatrics, Department of Neonatology, University Medical Centre 
      Ljubljana, Ljubljana, Slovenia. Electronic address: darja.paro@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170327
PL  - Singapore
TA  - Pediatr Neonatol
JT  - Pediatrics and neonatology
JID - 101484755
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Diagnostic Tests, Routine
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Milk Hypersensitivity/complications/*diagnosis
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
OTO - NOTNLM
OT  - allergy
OT  - exanthema
OT  - hematochezia
OT  - immunoglobulin E
OT  - newborn
EDAT- 2017/04/19 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/02/20 00:00 [received]
PHST- 2016/07/12 00:00 [revised]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2017/04/19 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/04/19 06:00 [entrez]
AID - S1875-9572(17)30174-2 [pii]
AID - 10.1016/j.pedneo.2016.09.009 [doi]
PST - ppublish
SO  - Pediatr Neonatol. 2017 Oct;58(5):449-454. doi: 10.1016/j.pedneo.2016.09.009. Epub 
      2017 Mar 27.