PMID- 28417199
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20191210
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 267
IP  - 5
DP  - 2017 Aug
TI  - Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive 
      deficits in adult offspring after maternal immune activation.
PG  - 479-483
LID - 10.1007/s00406-017-0802-1 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, 
      tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain 
      neurodevelopment. The exposure of pregnant mice to polyinosinic-polycytidylic 
      acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation 
      with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice 
      from pregnancy to weaning could prevent the onset of cognitive deficits and 
      reduced BDNF-TrkB signaling in the prefrontal cortex of their adult offspring. 
      These findings suggest that supplementation with a TrkB agonist in pregnant women 
      with an ultra-high risk of psychosis may reduce the development of psychosis in 
      their offspring.
FAU - Han, Mei
AU  - Han M
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, 260-8670, Japan.
AD  - School of Medicine, Illawarra Health and Medical Research Institute (IHMRI), 
      University of Wollongong, Wollongong, NSW, 2522, Australia.
FAU - Zhang, Ji-Chun
AU  - Zhang JC
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, 260-8670, Japan.
FAU - Huang, Xu-Feng
AU  - Huang XF
AD  - School of Medicine, Illawarra Health and Medical Research Institute (IHMRI), 
      University of Wollongong, Wollongong, NSW, 2522, Australia.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, 260-8670, Japan. hashimoto@faculty.chiba-u.jp.
LA  - eng
PT  - Journal Article
DEP - 20170417
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (6,7-dihydroxyflavone)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavones)
RN  - 0 (Interferon Inducers)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition Disorders/*etiology/pathology/*prevention & control
MH  - Disease Models, Animal
MH  - Drug Administration Schedule
MH  - Female
MH  - Flavones/*administration & dosage
MH  - Interferon Inducers/toxicity
MH  - Locomotion/drug effects
MH  - Male
MH  - Mice
MH  - Poly I-C/toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/drug 
      therapy/*physiopathology
MH  - Receptor, trkB/metabolism
MH  - Recognition, Psychology/drug effects
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - BDNF-TrkB signaling
OT  - Cognitive deficits
OT  - Prevention
OT  - Psychosis
EDAT- 2017/04/19 06:00
MHDA- 2018/01/31 06:00
CRDT- 2017/04/19 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/04/11 00:00 [accepted]
PHST- 2017/04/19 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
PHST- 2017/04/19 06:00 [entrez]
AID - 10.1007/s00406-017-0802-1 [pii]
AID - 10.1007/s00406-017-0802-1 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2017 Aug;267(5):479-483. doi: 
      10.1007/s00406-017-0802-1. Epub 2017 Apr 17.