PMID- 28419760 OWN - NLM STAT- MEDLINE DCOM- 20180509 LR - 20181202 IS - 1552-4965 (Electronic) IS - 1549-3296 (Linking) VI - 105 IP - 9 DP - 2017 Sep TI - Bone marrow-derived stem/stromal cells and adipose tissue-derived stem/stromal cells: Their comparative efficacies and synergistic effects. PG - 2640-2648 LID - 10.1002/jbm.a.36089 [doi] AB - Mesenchymal stem cells (MSCs) are heterogeneous cell populations that serve as reserves for tissue regeneration in the presence of disease or injury. Although MSCs are found in various tissues, bone marrow-derived stem/stromal cells (BMSCs) and adipose tissue-derived stem/stromal cells (ADSCs) have been most thoroughly investigated. Furthermore, ADSCs have recently emerged as an attractive source of MSCs due to their abundance and availability. BMSCs and ADSCs demonstrate similar morphological characteristics, but their in vitro characteristics and differentiation abilities appear to differ. In this review, the author summarizes and compares current knowledge on BMSCs and ADSCs with particular emphasis on in vitro expansion and osteogenic/angiogenic potential, and reviews knowledge of their synergistic effects when co-applied. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2640-2648, 2017. CI - (c) 2017 Wiley Periodicals, Inc. FAU - Im, Gun-Il AU - Im GI AD - Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea. LA - eng PT - Comparative Study PT - Journal Article PT - Review DEP - 20170517 PL - United States TA - J Biomed Mater Res A JT - Journal of biomedical materials research. Part A JID - 101234237 RN - 0 (Biomarkers) SB - IM MH - Adipose Tissue/cytology MH - Biomarkers/metabolism MH - Cell Proliferation MH - Humans MH - Mesenchymal Stem Cells/*cytology MH - Osteogenesis MH - Stromal Cells/cytology OTO - NOTNLM OT - adipose tissue-derived stem/stromal cells OT - angiogenesis OT - bone marrow-derived stem/stromal cells OT - osteogenesis OT - synergistic effect EDAT- 2017/04/19 06:00 MHDA- 2018/05/10 06:00 CRDT- 2017/04/19 06:00 PHST- 2017/01/22 00:00 [received] PHST- 2017/03/13 00:00 [revised] PHST- 2017/04/11 00:00 [accepted] PHST- 2017/04/19 06:00 [pubmed] PHST- 2018/05/10 06:00 [medline] PHST- 2017/04/19 06:00 [entrez] AID - 10.1002/jbm.a.36089 [doi] PST - ppublish SO - J Biomed Mater Res A. 2017 Sep;105(9):2640-2648. doi: 10.1002/jbm.a.36089. Epub 2017 May 17.