PMID- 28420072
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20180507
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 26
IP  - 10
DP  - 2017 Sep
TI  - Reduction of nitric oxide and DNA/RNA oxidation products are associated with 
      active disease in systemic lupus erythematosus patients.
PG  - 1106-1111
LID - 10.1177/0961203317692436 [doi]
AB  - The aims of the present study were to evaluate biomarkers of oxidative and 
      nitrosative stress in systemic lupus erythematosus (SLE) patients, in particular 
      products of DNA/RNA oxidative damage and their correlation with disease activity. 
      This study included 188 controls and 203 patients; 153 with inactive SLE 
      (SLEDAI < 6) and 50 with active SLE (SLEDAI >/= 6) without renal impairment. 
      Oxidative stress was assessed by tert-butyl hydroperoxide-initiated by 
      chemiluminescence, advanced oxidation protein products (AOPP), total 
      radical-trapping antioxidant parameter (TRAP), nitric oxide metabolites (NOx), 
      and DNA/RNA oxidation products. Patients with SLE showed increased oxidative 
      stress, as demonstrated by the augmentation of lipid hydroperoxides ( p < 0.0001) 
      and AOPP ( p < 0.001) and reduced total antioxidant capacity ( p < 0.0001), 
      without differences between patients with active disease and in remission. NOx 
      levels and DNA/RNA oxidation products were inversely and independently associated 
      with disease activity ( p < 0.0001 and p = 0.021, respectively), regardless of 
      BMI and prednisone use. The linear regression analysis showed that about 5% of 
      the SLEDAI score can be explained by the levels of DNA/RNA oxidation products ( 
      r(2):0.051; p = 0.002) and about 9% of this score by the levels of NOx ( 
      r(2):0.091; p < 0.0001). This study provides evidence for an inverse association 
      between serum NOx levels and DNA/RNA oxidation products and SLE disease activity, 
      suggesting that oxidative/nitrosative stress markers may be useful in evaluating 
      SLE disease activity and progression of the disease.
FAU - Iriyoda, T M V
AU  - Iriyoda TMV
AD  - 1 Department of Rheumatology, Pontificia Universidade Catolica (PUC) do Parana, 
      Brazil.
FAU - Stadtlober, N
AU  - Stadtlober N
AD  - 2 Post Graduate Program in Experimental Pathology, University of Londrina (UEL), 
      Brazil.
FAU - Lozovoy, M A B
AU  - Lozovoy MAB
AD  - 3 Department of Pathology, Clinical Analysis and Toxicology, University of 
      Londrina (UEL), Brazil.
FAU - Delongui, F
AU  - Delongui F
AD  - 4 Post Graduate Program in Health Sciences, University of Londrina (UEL), Brazil.
FAU - Costa, N T
AU  - Costa NT
AD  - 5 Department of Rheumatology, University of Londrina (UEL), Brazil.
FAU - Reiche, E M V
AU  - Reiche EMV
AD  - 3 Department of Pathology, Clinical Analysis and Toxicology, University of 
      Londrina (UEL), Brazil.
FAU - Dichi, I
AU  - Dichi I
AD  - 6 Department of Internal Medicine, University of Londrina (UEL), Brazil.
FAU - Simao, A N C
AU  - Simao ANC
AD  - 3 Department of Pathology, Clinical Analysis and Toxicology, University of 
      Londrina (UEL), Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170322
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Glucocorticoids)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Adult
MH  - Antioxidants/metabolism
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - DNA/metabolism
MH  - Disease Progression
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Linear Models
MH  - Lupus Erythematosus, Systemic/drug therapy/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*metabolism
MH  - Nitrosative Stress/*physiology
MH  - Oxidation-Reduction
MH  - Oxidative Stress/*physiology
MH  - Prednisone
MH  - RNA/metabolism
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - DNA oxidation
OT  - RNA oxidation
OT  - SLEDAI
OT  - Systemic lupus erythematosus
OT  - nitric oxide
OT  - oxidative stress
EDAT- 2017/04/20 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/04/20 06:00
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
AID - 10.1177/0961203317692436 [doi]
PST - ppublish
SO  - Lupus. 2017 Sep;26(10):1106-1111. doi: 10.1177/0961203317692436. Epub 2017 Mar 
      22.