PMID- 28420458
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20190201
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Print)
IS  - 0954-5794 (Linking)
VI  - 30
IP  - 1
DP  - 2018 Feb
TI  - Potentially important periods of change in the development of social and role 
      functioning in youth at clinical high risk for psychosis.
PG  - 39-47
LID - 10.1017/S0954579417000451 [doi]
AB  - The developmental course of daily functioning prior to first psychosis-onset 
      remains poorly understood. This study explored age-related periods of change in 
      social and role functioning. The longitudinal study included youth (aged 12-23, 
      mean follow-up years = 1.19) at clinical high risk (CHR) for psychosis 
      (converters [CHR-C], n = 83; nonconverters [CHR-NC], n = 275) and a healthy 
      control group (n = 164). Mixed-model analyses were performed to determine 
      age-related differences in social and role functioning. We limited our analyses 
      to functioning before psychosis conversion; thus, data of CHR-C participants 
      gathered after psychosis onset were excluded. In controls, social and role 
      functioning improved over time. From at least age 12, functioning in CHR was 
      poorer than in controls, and this lag persisted over time. Between ages 15 and 
      18, social functioning in CHR-C stagnated and diverged from that of CHR-NC, who 
      continued to improve (p = .001). Subsequently, CHR-C lagged behind in improvement 
      between ages 21 and 23, further distinguishing them from CHR-NC (p < .001). A 
      similar period of stagnation was apparent for role functioning, but to a lesser 
      extent (p = .007). The results remained consistent when we accounted for the time 
      to conversion. Our findings suggest that CHR-C start lagging behind CHR-NC in 
      social and role functioning in adolescence, followed by a period of further 
      stagnation in adulthood.
FAU - Velthorst, Eva
AU  - Velthorst E
AD  - Icahn School of Medicine at Mount Sinai.
FAU - Zinberg, Jamie
AU  - Zinberg J
AD  - University of California, Los Angeles.
FAU - Addington, Jean
AU  - Addington J
AD  - University of Calgary.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - University of California, San Diego.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Yale University.
FAU - Carrion, Ricardo E
AU  - Carrion RE
AD  - Hofstra Northwell School of Medicine.
FAU - Auther, Andrea
AU  - Auther A
AD  - Hofstra Northwell School of Medicine.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Hofstra Northwell School of Medicine.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Yale University.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - University of California, San Francisco.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - University of North Carolina, Chapel Hill.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Harvard Medical School at Beth Israel Deaconess Medical Center.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - University of California, San Diego.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Emory University.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Yale University.
FAU - Reichenberg, Abraham
AU  - Reichenberg A
AD  - Icahn School of Medicine at Mount Sinai.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - University of California, Los Angeles.
LA  - eng
GR  - K05 MH001654/MH/NIMH NIH HHS/United States
GR  - R01 MH065079/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - R01 MH061523/MH/NIMH NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - K23 MH001905/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - R01 MH062066/MH/NIMH NIH HHS/United States
GR  - U01 MH076989/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - R01 MH107250/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081944/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170419
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Psychotic Disorders/*psychology
MH  - *Social Adjustment
MH  - Young Adult
PMC - PMC5648633
MID - NIHMS909672
EDAT- 2017/04/20 06:00
MHDA- 2018/09/27 06:00
PMCR- 2019/02/01
CRDT- 2017/04/20 06:00
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - S0954579417000451 [pii]
AID - 10.1017/S0954579417000451 [doi]
PST - ppublish
SO  - Dev Psychopathol. 2018 Feb;30(1):39-47. doi: 10.1017/S0954579417000451. Epub 2017 
      Apr 19.