PMID- 28420543
OWN - NLM
STAT- MEDLINE
DCOM- 20171207
LR  - 20180206
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 220
IP  - 5
DP  - 2017 Jul
TI  - Serum persistent organic pollutants (POPs) and prostate cancer risk: A 
      case-cohort study.
PG  - 849-856
LID - S1438-4639(16)30539-9 [pii]
LID - 10.1016/j.ijheh.2017.03.014 [doi]
AB  - It is still unclear whether persistent organic pollutants (POPs) exposure 
      increases the prostate cancer incidence risk. This prospective cohort study 
      evaluated the associations between serum POPs concentrations and prostate cancer 
      risk. Within a case-cohort study, we identified 110 people diagnosed with 
      prostate cancer and randomly selected 256 sub-cohort participants without 
      prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) 
      congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard 
      ratios (HRs) and 95% confidence interval (95% CI) for determining the 
      associations between POPs and risk of prostate cancer were estimated using the 
      weighted Cox regression model. Compared to the lowest tertile, increased risks of 
      prostate cancer incidence were observed in the upper tertile of following PCBs: 
      the moderately chlorinated (HR: 4.19; 95% CI: 1.30-13.54), the highly chlorinated 
      (HR: 4.14; 95% CI: 1.75-9.79), biologically persistent as CYP1A and CYP2B 
      inducers (HR: 4.44; 95% CI: 1.33-14.83), the sum of non- dioxin-like (HR: 3.47; 
      95% CI: 1.21-9.98), and  summation operatorPCBs (HR: 4.29; 95% CI: 1.52-12.08). In dose-response 
      curves,  summation operatorPCBs was associated with the increased risk of prostate cancer. Our 
      findings suggested a possible role of POPs in the etiology of prostate cancer.
CI  - Copyright (c) 2017 Elsevier GmbH. All rights reserved.
FAU - Lim, Jung-Eun
AU  - Lim JE
AD  - Institute for Health Promotion & Department of Epidemiology and Health Promotion, 
      Graduate School of Public Health, Yonsei University, Seoul, South Korea; 
      Department of Public Health, Graduate School, Yonsei University, Seoul, South 
      Korea; College of Pharmacy, Ewha Womans University, Seoul, South Korea.
FAU - Nam, Chungmo
AU  - Nam C
AD  - Department of Biostatistics, College of Medicine, Yonsei University, South Korea.
FAU - Yang, Jiyeon
AU  - Yang J
AD  - Institute for Environmental Research, Yonsei University Health System, Seoul, 
      South Korea.
FAU - Rha, Koon Ho
AU  - Rha KH
AD  - Department of Urology, Urological Science Institute, Yonsei University College of 
      Medicine, Seoul, South Korea.
FAU - Lim, Kyung-Min
AU  - Lim KM
AD  - College of Pharmacy, Ewha Womans University, Seoul, South Korea.
FAU - Jee, Sun Ha
AU  - Jee SH
AD  - Institute for Health Promotion & Department of Epidemiology and Health Promotion, 
      Graduate School of Public Health, Yonsei University, Seoul, South Korea; 
      Department of Public Health, Graduate School, Yonsei University, Seoul, South 
      Korea. Electronic address: jsunha@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170410
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Middle Aged
MH  - Prostatic Neoplasms/blood/*epidemiology/etiology
MH  - Republic of Korea/epidemiology
MH  - Risk
OTO - NOTNLM
OT  - Cohort studies
OT  - Endocrine disruptors
OT  - Polychlorinated biphenyls
OT  - Prostatic neoplasms
EDAT- 2017/04/20 06:00
MHDA- 2017/12/08 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/11/18 00:00 [received]
PHST- 2017/03/31 00:00 [revised]
PHST- 2017/03/31 00:00 [accepted]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2017/12/08 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
AID - S1438-4639(16)30539-9 [pii]
AID - 10.1016/j.ijheh.2017.03.014 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2017 Jul;220(5):849-856. doi: 
      10.1016/j.ijheh.2017.03.014. Epub 2017 Apr 10.