PMID- 28421301
OWN - NLM
STAT- MEDLINE
DCOM- 20180424
LR  - 20181113
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 38
IP  - 8
DP  - 2017 Aug
TI  - Multiple sclerosis and amyotrophic lateral sclerosis: a human leukocyte antigen 
      challenge.
PG  - 1501-1503
LID - 10.1007/s10072-017-2939-0 [doi]
AB  - Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are two different 
      central nervous system pathology that, according to the most accredited 
      hypotheses, recognize a different etiopathogenesis. The simultaneous occurrence 
      of MS and ALS is quite unusual. To our knowledge, only three cases have been so 
      far described by clinical, laboratory, and post-mortem studies. We report four 
      new cases of this peculiar combination that have been observed and are herein 
      described, included their human leukocyte antigen (HLA) profile studies. On the 
      basis that three out of four patients in our case series presented HLA-B*18:01A, 
      we may hypothesize that this antigen could play a role in developing both 
      diseases.
FAU - Dattola, Vincenzo
AU  - Dattola V
AUID- ORCID: 0000-0002-1457-1029
AD  - IRCCS Centro Neurolesi "Bonino-Pulejo", Contrada Casazza, SS113, 98124, Messina, 
      Italy. vincenzo.dattola@gmail.com.
FAU - Fama, Fausto
AU  - Fama F
AD  - Department of Human Pathology, University Hospital of Messina, Messina, Italy.
FAU - Russo, Margherita
AU  - Russo M
AD  - IRCCS Centro Neurolesi "Bonino-Pulejo", Contrada Casazza, SS113, 98124, Messina, 
      Italy.
FAU - Calabro, Rocco Salvatore
AU  - Calabro RS
AD  - IRCCS Centro Neurolesi "Bonino-Pulejo", Contrada Casazza, SS113, 98124, Messina, 
      Italy.
FAU - Logiudice, Anna Lisa
AU  - Logiudice AL
AD  - IRCCS Centro Neurolesi "Bonino-Pulejo", Contrada Casazza, SS113, 98124, Messina, 
      Italy.
FAU - Grasso, Maria Grazia
AU  - Grasso MG
AD  - Multiple Sclerosis Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.
FAU - Patti, Francesco
AU  - Patti F
AD  - Department of Neurology, University Hospital of Catania, Catania, Italy.
FAU - Buccafusca, Maria
AU  - Buccafusca M
AD  - Department of Clinical and Experimental Medicine, University Hospital of Messina, 
      Messina, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Amyotrophic Lateral Sclerosis/*metabolism
MH  - Female
MH  - HLA Antigens/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*metabolism
OTO - NOTNLM
OT  - Amyotrophic lateral sclerosis
OT  - Histocompatibility antigens
OT  - Human leukocyte antigen
OT  - Multiple sclerosis
EDAT- 2017/04/20 06:00
MHDA- 2018/04/25 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/11/15 00:00 [received]
PHST- 2017/03/27 00:00 [accepted]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2018/04/25 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
AID - 10.1007/s10072-017-2939-0 [pii]
AID - 10.1007/s10072-017-2939-0 [doi]
PST - ppublish
SO  - Neurol Sci. 2017 Aug;38(8):1501-1503. doi: 10.1007/s10072-017-2939-0. Epub 2017 
      Apr 18.