PMID- 28421317
OWN - NLM
STAT- MEDLINE
DCOM- 20171207
LR  - 20181202
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 31
IP  - 3
DP  - 2017 Jun
TI  - Effect of oral carbohydrate with amino acid solution on serum 
      oxidative/anti-oxidative status in healthy volunteers.
PG  - 472-475
LID - 10.1007/s00540-017-2355-x [doi]
AB  - The aim of this work was to investigate the effect of oral carbohydrate with 
      amino acid [oral nutritional supplement (ONS)] solution on oxidative stress in 
      healthy persons. Fourteen healthy volunteers were segregated into control and ONS 
      groups. Volunteers in the ONS group ingested 250 ml of Arginaid Water (Nestle 
      Japan, Tokyo, Japan) in the evening before the experiment and at 7:00 am on the 
      day of the experiment. Volunteers in the control group fasted after dinner and 
      drank only water until 7:00 am on the day of the experiment. In both groups, 
      blood was collected at 9:00 am. The serum total oxidant levels and antioxidant 
      capacity were assessed by d-ROMs (derivatives of reactive oxygen metabolites) 
      test and BAP (biological antioxidant potential) test, respectively. In the ONS 
      group, the serum d-ROMs level was significantly lower than in the control group 
      (297 +/- 43 and 327 +/- 41 U.CARR, respectively, p = 0.018), while the serum BAP 
      level was significantly higher than the control group (2410 +/- 432 and 
      1979 +/- 397 micromol/l, respectively, p = 0.005). The OXY level of Arginaid Water was 
      much higher than preOp drink (Nutricia, Ireland). In conclusion, our study showed 
      that an ONS with arginine loading could decrease oxidative stress and increase 
      antioxidant capacity in healthy volunteers.
FAU - Tsutsumi, Yasuo M
AU  - Tsutsumi YM
AD  - Department of Anesthesiology, Tokushima University, Tokushima, Japan. 
      tsutsumi@tokushima-u.ac.jp.
FAU - Oyama, Takuro
AU  - Oyama T
AD  - Department of Anesthesiology, Tokushima University, Tokushima, Japan.
FAU - Kakuta, Nami
AU  - Kakuta N
AD  - Department of Anesthesiology, Tokushima University, Tokushima, Japan.
FAU - Horikawa, Yousuke T
AU  - Horikawa YT
AD  - Department of Anesthesiology, Tokushima University, Tokushima, Japan.
AD  - Department of Pediatrics, Sharp Rees-Stealy, San Diego, CA, USA.
FAU - Kume, Katsuyoshi
AU  - Kume K
AD  - Department of Anesthesiology, Tokushima University, Tokushima, Japan.
FAU - Sakai, Yoko
AU  - Sakai Y
AD  - Department of Anesthesiology, Tokushima University, Tokushima, Japan.
FAU - Tsutsumi, Rie
AU  - Tsutsumi R
AD  - Department of Nutrition, Tokushima University, Tokushima, Japan.
FAU - Tanaka, Katsuya
AU  - Tanaka K
AD  - Department of Anesthesiology, Tokushima University, Tokushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Amino Acids)
RN  - 0 (Antioxidants)
RN  - 0 (Carbohydrates)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Amino Acids/*administration & dosage
MH  - Antioxidants/*metabolism
MH  - Carbohydrates/*administration & dosage
MH  - Cross-Over Studies
MH  - Fasting
MH  - Humans
MH  - Japan
MH  - Oxidative Stress/*drug effects
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - Oral carbohydrate with amino acid solution
OT  - Serum anti-oxidative status
OT  - Serum oxidative status
EDAT- 2017/04/20 06:00
MHDA- 2017/12/08 06:00
CRDT- 2017/04/20 06:00
PHST- 2017/02/17 00:00 [received]
PHST- 2017/04/05 00:00 [accepted]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2017/12/08 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
AID - 10.1007/s00540-017-2355-x [pii]
AID - 10.1007/s00540-017-2355-x [doi]
PST - ppublish
SO  - J Anesth. 2017 Jun;31(3):472-475. doi: 10.1007/s00540-017-2355-x. Epub 2017 Apr 
      18.