PMID- 28422000
OWN - NLM
STAT- MEDLINE
DCOM- 20170831
LR  - 20170831
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 35 Suppl 105
IP  - 3
DP  - 2017 May-Jun
TI  - Fibromyalgia in 300 adult index patients with primary immunodeficiency.
PG  - 68-73
AB  - OBJECTIVES: We sought to determine the prevalence and clinical and laboratory 
      associations of fibromyalgia in adults with primary immunodeficiency 
      (immunoglobulin (Ig) G subclass deficiency (IgGSD) and common variable 
      immunodeficiency (CVID). METHODS: We performed a retrospective analysis of these 
      observations in 300 non-Hispanic white adult index patients with recurrent/severe 
      respiratory tract infections and IgGSD or CVID: age; sex; IgGSD; fibromyalgia; 
      chronic fatigue; autoimmune conditions (ACs); interstitial cystitis (IC); 
      diabetes; body mass index; serum Ig isotypes; blood lymphocytes and subsets; and 
      human leukocyte antigen (HLA)-A and -B types and haplotypes. We performed 
      univariate comparisons, logistic multivariable regressions, and an analysis of 
      covariance. RESULTS: Mean age was 49 +/- 12 (standard deviation) y. There were 246 
      women (82.0%). IgGSD was diagnosed in 276 patients (92.0%). Fifty-six patients 
      had fibromyalgia (18.7%; female:male 13:1). Other characteristics included: 
      chronic fatigue, 63.0%; aggregate ACs, 35.3%; Sjogren's syndrome, 8.0%; IC, 3.0%; 
      diabetes, 10.3%; and HLA-A*29, B*44 positivity, 9.7%. Prevalences of female sex; 
      chronic fatigue; IC; and HLA-A*29, B*44 positivity were greater in patients with 
      fibromyalgia. Logistic regression on fibromyalgia revealed three positive 
      associations: chronic fatigue (p=0.0149; odds ratio 2.6 [95% confidence interval 
      1.2, 5.6]); Sjogren's syndrome (p=0.0004; 5.2 [2.1, 13.2]); and IC (p=0.0232; 5.7 
      [1.3, 25.7]). In an analysis of covariance, there were significant interactions 
      of chronic fatigue, Sjogren's syndrome, and interstitial cystitis on 
      fibromyalgia. CONCLUSIONS: Fibromyalgia is common in non-Hispanic white adult 
      index patients with primary immunodeficiency, especially women. Chronic fatigue, 
      Sjogren's syndrome, and IC are significantly associated with fibromyalgia after 
      adjustment for other independent variables.
FAU - Barton, James C
AU  - Barton JC
AD  - Department of Medicine, Brookwood Medical Center, Birmingham, AL; Southern Iron 
      Disorders Center, Birmingham, AL; and Department of Medicine, University of 
      Alabama at Birmingham, AL, USA. ironmd@isp.com.
FAU - Bertoli, Luigi F
AU  - Bertoli LF
AD  - Department of Medicine, Brookwood Medical Center, Birmingham, AL; Southern Iron 
      Disorders Center, Birmingham, AL; and Brookwood Biomedical, Birmingham, AL, USA.
FAU - Barton, Jackson C
AU  - Barton JC
AD  - Southern Iron Disorders Center, Birmingham, AL, USA.
FAU - Acton, Ronald T
AU  - Acton RT
AD  - Southern Iron Disorders Center, Birmingham, AL; and Department of Microbiology, 
      University of Alabama at Birmingham, USA.
LA  - eng
PT  - Journal Article
DEP - 20170419
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A29 antigen)
RN  - 0 (HLA-B44 Antigen)
SB  - IM
MH  - Adult
MH  - Autoimmune Diseases/epidemiology
MH  - Common Variable Immunodeficiency/*epidemiology/genetics
MH  - Cystitis, Interstitial/epidemiology
MH  - Fatigue Syndrome, Chronic/epidemiology
MH  - Female
MH  - Fibromyalgia/*epidemiology/genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B44 Antigen/genetics
MH  - Haplotypes
MH  - Humans
MH  - IgG Deficiency/*epidemiology/genetics
MH  - Immunologic Deficiency Syndromes/epidemiology/genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Retrospective Studies
MH  - Sjogren's Syndrome/*epidemiology
EDAT- 2017/04/20 06:00
MHDA- 2017/09/01 06:00
CRDT- 2017/04/20 06:00
PHST- 2017/01/28 00:00 [received]
PHST- 2017/03/28 00:00 [accepted]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2017/09/01 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
AID - 11556 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2017 May-Jun;35 Suppl 105(3):68-73. Epub 2017 Apr 19.