PMID- 28422703
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20180131
IS  - 1868-503X (Electronic)
IS  - 1868-5021 (Linking)
VI  - 8
IP  - 2
DP  - 2017 May 24
TI  - Differential hemoglobin A sequestration between hemodialysis modalities.
PG  - 125-129
LID - 10.1515/bmc-2017-0006 [doi]
AB  - This report evaluates plasma protein patterns, dialysates and protein analysis of 
      used dialysis membranes from the same patient under hemodialysis in three 
      separate modalities, using high-flux membranes in concentration-driven transport 
      (HD), convection-driven hemofiltration (HF) and combined hemodialfiltration 
      (HDF). The plasma protein changes induced by each of the three dialysis 
      modalities showed small differences in proteins identified towards our previous 
      plasma analyses of chronic kidney disease (CKD) patients. The used dialysate 
      peptide concentrations likewise exhibited small differences among the modalities 
      and varied in the same relative order as the plasma changes, with protein losses 
      in the order HD>HDF>HF. The membrane protein deposits allowed quantification of 
      the relative Hb removal ratios as ~1.7 for HD and ~1.2 for HDF vs. ~1.0 for HF. 
      Hence, plasma protein alterations, dialysate peptide contents and membrane Hb 
      deposits all identify HD as the modality with the most extensive filtration 
      results and exemplifies the accessibility of protein analysis of used membrane 
      filters for evaluation of dialysis efficiencies.
FAU - Naseeb, Uzma
AU  - Naseeb U
AD  - .
FAU - Zarina, Shamshad
AU  - Zarina S
AD  - .
FAU - Jagerbrink, Theres
AU  - Jagerbrink T
AD  - .
FAU - Shafqat, Jawed
AU  - Shafqat J
AD  - .
FAU - Jornvall, Hans
AU  - Jornvall H
AD  - .
FAU - Axelsson, Jonas
AU  - Axelsson J
AD  - .
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Biomol Concepts
JT  - Biomolecular concepts
JID - 101518829
RN  - 0 (Blood Proteins)
RN  - 9034-51-9 (Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Blood Proteins/analysis
MH  - Chromatography, High Pressure Liquid
MH  - Hemoglobin A/analysis/*metabolism
MH  - Humans
MH  - Male
MH  - Proteomics
MH  - Renal Dialysis/*methods
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
OTO - NOTNLM
OT  - hemodialysis modalities
OT  - hemoglobin
OT  - plasma
OT  - protein
EDAT- 2017/04/20 06:00
MHDA- 2018/02/01 06:00
CRDT- 2017/04/20 06:00
PHST- 2017/02/09 00:00 [received]
PHST- 2017/03/09 00:00 [accepted]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
AID - /j/bmc.ahead-of-print/bmc-2017-0006/bmc-2017-0006.xml [pii]
AID - 10.1515/bmc-2017-0006 [doi]
PST - ppublish
SO  - Biomol Concepts. 2017 May 24;8(2):125-129. doi: 10.1515/bmc-2017-0006.