PMID- 28422857
OWN - NLM
STAT- MEDLINE
DCOM- 20170509
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 16
DP  - 2017 Apr
TI  - Serum resistin positively correlates with serum lipids, but not with insulin 
      resistance, in first-degree relatives of type-2 diabetes patients: an 
      observational study in China.
PG  - e6622
LID - 10.1097/MD.0000000000006622 [doi]
LID - e6622
AB  - To investigate whether serum resistin correlated with hypertension, obesity, 
      dyslipidemia, or insulin resistance (IR) in Chinese type 2 diabetes mellitus 
      (T2DM) patients and their first-degree relatives (DFDRs) in a case-control 
      observational study.We determined the serum levels of resistin, plasma lipids, 
      glucose, and insulin, and performed clinical assessments of hypertension, 
      obesity, and IR for 42 T2DM patients, 74 of their DFDRs, and 51 healthy control 
      participants with no family history of T2DM (NC group). The biochemical and 
      clinical variables were compared between the 3 groups, and relationships between 
      serum resistin and the other variables were evaluated using a Pearson correlation 
      analysis.Significant trends were observed in the triglyceride, HbA1c, and 
      resistin levels, in which the values observed in the DFDR group were intermediate 
      to those of the T2DM and NC groups (P < .05 for all). A stratified analysis 
      revealed significant trends in the resistin level and scores for homeostasis 
      model assessment (HOMA) indexes for IR and insulin sensitivity in women and in 
      the HbA1c and resistin levels in men (P < .05 for all), with DFDR subjects 
      exhibiting intermediate values. The Pearson analysis showed that serum resistin 
      positively correlated with total cholesterol and low-density lipoprotein 
      cholesterol in the DFDR group only (P < .05 for both), and that resistin did not 
      correlate significantly with HOMA indexes, blood glucose, insulin, HbA1c, 
      triglyceride, high-density lipoprotein cholesterol, BMI, waist or hip 
      circumference, or blood pressure.Our results suggest that elevated serum resistin 
      might contribute to an increased risk of hyperlipidemia in DFDRs of Chinese T2DM 
      patients.
FAU - Niu, Xiao-Hong
AU  - Niu XH
AD  - aDepartment of Endocrinology bClinical Laboratory, Heji Hospital Affiliated to 
      Changzhi Medical College, Changzhi, China.
FAU - Li, Li
AU  - Li L
FAU - Li, Jun-Yan
AU  - Li JY
FAU - Song, Qi
AU  - Song Q
FAU - Jin, Miao-Miao
AU  - Jin MM
FAU - Liu, Jin-Xia
AU  - Liu JX
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Resistin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose
MH  - Blood Pressure
MH  - Body Mass Index
MH  - China
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology/physiopathology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hyperlipidemias/blood/epidemiology
MH  - Hypertension/blood/epidemiology
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/epidemiology
MH  - Resistin/*blood
PMC - PMC5406073
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2017/04/20 06:00
MHDA- 2017/05/10 06:00
PMCR- 2017/04/21
CRDT- 2017/04/20 06:00
PHST- 2017/04/20 06:00 [entrez]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
PHST- 2017/04/21 00:00 [pmc-release]
AID - 00005792-201704210-00038 [pii]
AID - MD-D-16-06361 [pii]
AID - 10.1097/MD.0000000000006622 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Apr;96(16):e6622. doi: 10.1097/MD.0000000000006622.