PMID- 28423181
OWN - NLM
STAT- MEDLINE
DCOM- 20170920
LR  - 20201209
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 152
IP  - 1
DP  - 2017 Sep
TI  - Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cells highly induce 
      regulatory T cells.
PG  - 52-64
LID - 10.1111/imm.12747 [doi]
AB  - Dendritic cells (DCs) in mesenteric lymph nodes (MLNs) induce Foxp3(+) regulatory 
      T cells to regulate immune responses to beneficial or non-harmful agents in the 
      intestine, such as commensal bacteria and foods. Several studies in MLN DCs have 
      revealed that the CD103(+) DC subset highly induces regulatory T cells, and 
      another study has reported that MLN DCs from programmed death ligand 1 (PD-L1) 
      -deficient mice could not induce regulatory T cells. Hence, the present study 
      investigated the expression of these molecules on MLN CD11c(+) cells. Four 
      distinct subsets expressing CD103 and/or PD-L1 were identified, namely CD11b(+) 
      CD103(+) PD-L1(High) , CD11b(-) CD103(+) PD-L1(High) , CD11b(-) CD103(+) 
      PD-L1(Low) and CD11b(+) CD103(-) PD-L1(Int) . Among them, the CD11b(-) CD103(+) 
      PD-L1(High) DC subset highly induced Foxp3(+) T cells. This subset expressed 
      Aldh1a2 and Itgb8 genes, which are involved in retinoic acid metabolism and 
      transforming growth factor-beta (TGF-beta) activation, respectively. Exogenous TGF-beta 
      supplementation equalized the level of Foxp3(+) T-cell induction by the four 
      subsets whereas retinoic acid did not, which suggests that high ability to 
      activate TGF-beta is determinant for the high Foxp3(+) T-cell induction by CD11b(-) 
      CD103(+) PD-L1(High) DC subset. Finally, this subset exhibited a migratory DC 
      phenotype and could take up and present orally administered antigens. 
      Collectively, the MLN CD11b(-) CD103(+) PD-L1(High) DC subset probably takes up 
      luminal antigens in the intestine, migrates to MLNs, and highly induces 
      regulatory T cells through TGF-beta activation.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Shiokawa, Aya
AU  - Shiokawa A
AD  - Research Center for Food Safety, Graduate School of Agricultural and Life 
      Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Kotaki, Ryutaro
AU  - Kotaki R
AUID- ORCID: 0000-0001-7965-1671
AD  - Research Center for Food Safety, Graduate School of Agricultural and Life 
      Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Takano, Tomohiro
AU  - Takano T
AD  - Research Center for Food Safety, Graduate School of Agricultural and Life 
      Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Nakajima-Adachi, Haruyo
AU  - Nakajima-Adachi H
AD  - Research Center for Food Safety, Graduate School of Agricultural and Life 
      Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
FAU - Hachimura, Satoshi
AU  - Hachimura S
AD  - Research Center for Food Safety, Graduate School of Agricultural and Life 
      Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170601
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antigens, CD)
RN  - 0 (B7-H1 Antigen)
RN  - 0 (CD11b Antigen)
RN  - 0 (Cd274 protein, mouse)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Integrin beta Chains)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (alpha E integrins)
RN  - 0 (integrin beta8)
RN  - 5688UTC01R (Tretinoin)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 1.2.1 (Aldehyde Dehydrogenase 1 Family)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
RN  - EC 1.2.1.36 (Aldh1a2 protein, mouse)
RN  - EC 1.2.1.36 (Retinal Dehydrogenase)
SB  - IM
MH  - Administration, Oral
MH  - Aldehyde Dehydrogenase/immunology/metabolism
MH  - Aldehyde Dehydrogenase 1 Family
MH  - Animals
MH  - Antigens, CD/*immunology/metabolism
MH  - B7-H1 Antigen/*immunology/metabolism
MH  - CD11b Antigen/*immunology/metabolism
MH  - *Cell Communication/drug effects
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Dendritic Cells/drug effects/*immunology/metabolism
MH  - Forkhead Transcription Factors/immunology/metabolism
MH  - Immunity, Mucosal
MH  - Integrin alpha Chains/*immunology/metabolism
MH  - Integrin beta Chains/immunology/metabolism
MH  - Intestinal Mucosa/metabolism
MH  - Intestines/cytology/drug effects/*immunology
MH  - Lymph Nodes/cytology/drug effects/*immunology/metabolism
MH  - Mesentery
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/administration & dosage/immunology
MH  - Phenotype
MH  - Retinal Dehydrogenase
MH  - Signal Transduction
MH  - T-Lymphocytes, Regulatory/drug effects/*immunology/metabolism
MH  - Transforming Growth Factor beta/immunology/metabolism
MH  - Tretinoin/pharmacology
PMC - PMC5543494
OTO - NOTNLM
OT  - dendritic cells
OT  - intestinal immunity
OT  - mesenteric lymph nodes
OT  - oral tolerance
OT  - regulatory T cells
EDAT- 2017/04/20 06:00
MHDA- 2017/09/21 06:00
PMCR- 2018/09/01
CRDT- 2017/04/20 06:00
PHST- 2016/11/26 00:00 [received]
PHST- 2017/04/02 00:00 [revised]
PHST- 2017/04/09 00:00 [accepted]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2017/09/21 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
PHST- 2018/09/01 00:00 [pmc-release]
AID - IMM12747 [pii]
AID - 10.1111/imm.12747 [doi]
PST - ppublish
SO  - Immunology. 2017 Sep;152(1):52-64. doi: 10.1111/imm.12747. Epub 2017 Jun 1.