PMID- 28423375
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20180220
IS  - 2296-5262 (Electronic)
IS  - 2296-5270 (Linking)
VI  - 40
IP  - 5
DP  - 2017
TI  - Evaluation of Short-Term Efficacy of Concurrent Chemoradiotherapy in Primary 
      Fallopian Tube Carcinoma by Diffusion-Weighted Imaging: A Retrospective Study.
PG  - 281-287
LID - 10.1159/000464354 [doi]
AB  - BACKGROUND: This study aims to evaluate the short-term efficacy of concurrent 
      chemoradiotherapy (CCRT) in primary fallopian tube carcinoma (PFTC) using 
      magnetic resonance diffusion-weighted imaging (MR-DWI). PATIENTS AND METHODS: 
      Total abdominal irradiation was performed for 61 PFTC patients after surgery, and 
      paclitaxel and carboplatin were used for CCRT. According to the response 
      evaluation criteria in solid tumors (RECIST1.1), patients were divided into a 
      sensitive (n = 36) and a resistant group (n = 25). Pearson correlation analysis 
      was conducted to assess the correlations of tumor regression rate with apparent 
      diffusion coefficient (ADC)pre, ADCpost, and ∆ADCpost. The efficacy of CCRT in 
      PFTC using MR-DWI was evaluated by ROC curve, logistic regression analysis, 
      Kaplan-Meier survival curve, and Cox regression model. RESULTS: The ADCpre in 
      both the sensitive and the resistant group was negatively associated with the 
      tumor regression rate (r = -0.508), while the ADCpost (r = 0.454) and ∆ADCpost (r 
      = 0.769) were positively associated with the tumor regression rate (all p < 
      0.05). Histopathological type, FIGO stage, lymphatic metastasis, tumor regression 
      rate, ADCpre, ADCpost, and ∆ADCpost were confirmed as key factors for CCRT in 
      PFTC (all p < 0.05). CONCLUSION: Our retrospective study demonstrates the 
      predictive value of MR-DWI in CCRT for PFTC patients.
CI  - (c) 2017 S. Karger GmbH, Freiburg.
FAU - Liu, Ye-Wei
AU  - Liu YW
FAU - Du, Ya-Fei
AU  - Du YF
FAU - Zhang, Hong-Zhen
AU  - Zhang HZ
FAU - Fang, Gui-Ying
AU  - Fang GY
FAU - Zhang, Yu-Xiang
AU  - Zhang YX
FAU - Ge, Jing
AU  - Ge J
FAU - Liu, Jing
AU  - Liu J
LA  - eng
PT  - Journal Article
DEP - 20170420
PL  - Switzerland
TA  - Oncol Res Treat
JT  - Oncology research and treatment
JID - 101627692
SB  - IM
MH  - Chemoradiotherapy/*methods
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Drug Monitoring/*methods
MH  - Fallopian Tube Neoplasms/*diagnostic imaging/pathology/*therapy
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Concurrent chemoradiotherapy
OT  - Diffusion-weighted imaging
OT  - Magnetic resonance
OT  - Primary fallopian tube carcinoma
EDAT- 2017/04/20 06:00
MHDA- 2018/02/21 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/10/13 00:00 [received]
PHST- 2017/02/21 00:00 [accepted]
PHST- 2017/04/20 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2017/04/20 06:00 [entrez]
AID - 000464354 [pii]
AID - 10.1159/000464354 [doi]
PST - ppublish
SO  - Oncol Res Treat. 2017;40(5):281-287. doi: 10.1159/000464354. Epub 2017 Apr 20.