PMID- 28423486
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 13
DP  - 2017 Mar 28
TI  - Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with 
      anaphylaxis to tick bite.
PG  - 20630-20644
LID - 10.18632/oncotarget.15243 [doi]
AB  - Tick-borne infectious diseases and allergies are a growing problem worldwide. 
      Tick bite allergy has been associated with the direct effect of immunoglobulin E 
      (IgE) response to tick salivary antigens, or secondary to the induction of 
      allergy to red meat consumption through IgE antibodies against the carbohydrate 
      alpha-Gal (Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R). However, despite the growing burden of 
      this pathology, the proteins associated with anaphylaxis to tick bite have not 
      been characterized. To address this question, a comparative proteomics approach 
      was used to characterize tick proteins producing an IgE antibody response in a 
      healthy individual with record of tick bites, which had not resulted in any 
      allergic reactions, and two patients with anaphylactic reactions to Rhipicephalus 
      bursa or Hyalomma marginatum tick bites. Both patients and the healthy individual 
      were red meat tolerant. The results supported a patient-specific IgE antibody 
      response to tick species responsible for the anaphylaxis to tick bite. Both 
      patients and the healthy individual serologically recognized tick proteins with 
      and without alpha-Gal modifications, with proteins differentially recognized by 
      patients but not control sera. These proteins could be used as potential antigens 
      for diagnostics, treatment and prevention of tick bite-induced allergies.
FAU - Mateos-Hernandez, Lourdes
AU  - Mateos-Hernandez L
AD  - SaBio, Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      Ciudad Real, Spain.
FAU - Villar, Margarita
AU  - Villar M
AD  - SaBio, Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      Ciudad Real, Spain.
FAU - Moral, Angel
AU  - Moral A
AD  - Department of Allergy, Hospital Virgen del Valle, Toledo, Spain.
FAU - Rodriguez, Carmen Garcia
AU  - Rodriguez CG
AD  - Allergy Section, General University Hospital of Ciudad Real, Ciudad Real, Spain.
FAU - Arias, Teresa Alfaya
AU  - Arias TA
AD  - Allergy Section, General University Hospital of Ciudad Real, Ciudad Real, Spain.
FAU - de la Osa, Veronica
AU  - de la Osa V
AD  - Department of Allergy, Hospital Virgen del Valle, Toledo, Spain.
FAU - Brito, Francisco Feo
AU  - Brito FF
AD  - Allergy Section, General University Hospital of Ciudad Real, Ciudad Real, Spain.
FAU - Fernandez de Mera, Isabel G
AU  - Fernandez de Mera IG
AD  - SaBio, Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      Ciudad Real, Spain.
FAU - Alberdi, Pilar
AU  - Alberdi P
AD  - SaBio, Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      Ciudad Real, Spain.
FAU - Ruiz-Fons, Francisco
AU  - Ruiz-Fons F
AD  - SaBio, Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      Ciudad Real, Spain.
FAU - Cabezas-Cruz, Alejandro
AU  - Cabezas-Cruz A
AD  - Institute of Parasitology, Biology Center of the Academy of Sciences of The Czech 
      Republic, Ceske Budejovice, Czech Republic.
AD  - Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech 
      Republic.
FAU - Estrada-Pena, Agustin
AU  - Estrada-Pena A
AD  - Department of Animal Pathology, Faculty of Veterinary Medicine, University of 
      Zaragoza, Miguel Servet, Zaragoza, Spain.
FAU - de la Fuente, Jose
AU  - de la Fuente J
AD  - SaBio, Instituto de Investigacion de Recursos Cinegeticos, IREC-CSIC-UCLM-JCCM, 
      Ciudad Real, Spain.
AD  - Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, 
      Oklahoma State University, Stillwater, Oklahoma, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Antigens)
RN  - 0 (Arthropod Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anaphylaxis/*immunology
MH  - Animals
MH  - Antigens/immunology
MH  - Arthropod Proteins/*immunology
MH  - Blotting, Western
MH  - Electrophoresis, Gel, Two-Dimensional
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Middle Aged
MH  - Proteomics
MH  - Tick Bites/complications/*immunology
MH  - Ticks/*immunology
PMC - PMC5400532
OTO - NOTNLM
OT  - Immune response
OT  - Immunity
OT  - Immunology and Microbiology Section
OT  - allergy
OT  - alpha-Gal
OT  - anaphylaxis
OT  - immunology
OT  - proteomics
COIS- CONFLICTS OF INTEREST The authors declare no commercial or financial conflict of 
      interest.
EDAT- 2017/04/21 06:00
MHDA- 2017/09/28 06:00
PMCR- 2017/03/28
CRDT- 2017/04/21 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2017/01/28 00:00 [accepted]
PHST- 2017/04/21 06:00 [entrez]
PHST- 2017/04/21 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2017/03/28 00:00 [pmc-release]
AID - 15243 [pii]
AID - 10.18632/oncotarget.15243 [doi]
PST - ppublish
SO  - Oncotarget. 2017 Mar 28;8(13):20630-20644. doi: 10.18632/oncotarget.15243.