PMID- 28424752
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-8334 (Print)
IS  - 2090-8342 (Electronic)
IS  - 2090-8342 (Linking)
VI  - 5
DP  - 2016
TI  - Cocaine-Like Discriminative Stimulus Effects of Mephedrone and Naphyrone in Mice.
LID - 236009 [pii]
LID - 10.4303/jdar/236009 [doi]
AB  - BACKGROUND: In recent years, commercial bath salts products containing synthetic 
      cathinone analogues have emerged as illicit drugs of abuse. These cathinones are 
      structurally similar to the psychostimulants 3,4-methylenedioxymethamphetamine 
      (MDMA) and methamphetamine (METH), and produce their effects via interactions 
      with monoamine transporters, where smaller compounds (e.g., mephedrone) are 
      amphetamine-like monoamine releasers, while the structurally larger compounds 
      (e.g., naphyrone) are cocaine-like monoamine reuptake inhibitors. Individual 
      cathinones also differ from one another with respect to selectivity among the 
      three monoamine transporters. STATEMENT OF PURPOSE OF STUDY: This study was 
      designed to assess the cocaine-like interoceptive effects of synthetic cathinone 
      analogues functioning as passive monoamine reuptake inhibitors (naphyrone) or as 
      releasers (mephedrone) in mice in order to compare effectiveness (degree of 
      substitution) and potency with positive control psychostimulants cocaine, METH, 
      and MDMA. PROCEDURES: In the present study, mice were trained to discriminate 10 
      mg/kg cocaine from saline, and substitutions with METH, MDMA, mephedrone, 
      naphyrone, and morphine were performed. MAIN FINDINGS: Mice reliably 
      discriminated the cocaine training dose from saline, and METH, MDMA, mephedrone, 
      and naphyrone all elicited full cocaine-like responding, while morphine did not. 
      Potency differences were observed such that METH was most potent, while 
      mephedrone, cocaine, MDMA, and naphyrone exhibited roughly equivalent potency. 
      PRINCIPAL CONCLUSIONS: These data confirm that interaction with DAT is an 
      important component of cocaine-like discriminative stimulus effects, and suggest 
      that synthetic cathinones likely elicit psychostimulant-like abuse-related 
      effects.
FAU - Gannon, Brenda M
AU  - Gannon BM
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
FAU - Fantegrossi, William E
AU  - Fantegrossi WE
AD  - Department of Pharmacology and Toxicology, College of Medicine, University of 
      Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
LA  - eng
GR  - P30 GM110702/GM/NIGMS NIH HHS/United States
GR  - R01 DA039195/DA/NIDA NIH HHS/United States
GR  - T32 DA022981/DA/NIDA NIH HHS/United States
GR  - UL1 TR000039/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20161231
PL  - Egypt
TA  - J Drug Alcohol Res
JT  - Journal of drug and alcohol research
JID - 101597241
PMC - PMC5393345
MID - NIHMS850763
OTO - NOTNLM
OT  - bath salts
OT  - cathinones
OT  - drug discrimination
COIS- Conflict of interest The authors declare that they have no conflict of interest.
EDAT- 2016/01/01 00:00
MHDA- 2016/01/01 00:01
PMCR- 2017/04/17
CRDT- 2017/04/21 06:00
PHST- 2017/04/21 06:00 [entrez]
PHST- 2016/01/01 00:00 [pubmed]
PHST- 2016/01/01 00:01 [medline]
PHST- 2017/04/17 00:00 [pmc-release]
AID - 236009 [pii]
AID - 10.4303/jdar/236009 [doi]
PST - ppublish
SO  - J Drug Alcohol Res. 2016;5:236009. doi: 10.4303/jdar/236009. Epub 2016 Dec 31.