PMID- 28425336
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 123
IP  - 1
DP  - 2003 Jan 1
TI  - Protective Efect of Brain-derived Neurotrophic Factor Against the Ototoxicity of 
      Pseudomonas aeruginosa Exotoxin A.
PG  - 14-19
LID - 10.1080/0036554021000028090 [doi]
AB  - Objective--The protective effect of brain-derived neurotrophic factor (BDNF) 
      against the ototoxicity resulting from exposure of Pseudomonas aeruginosa 
      exotoxin A (PaExoA) to the middle ear was analyzed. The combined effect of BDNF 
      and N(G)-nitro-L-arginine methyl ester (L-NAME) was also investigated. Material 
      and methods--Six groups of albino rats were instilled through the tympanic 
      membrane into the round window niche with the following solutions: saline; 
      PaExoA; BDNF; L-NAME; PaExoA + BDNF; and PaExoA + BDNF + L-NAME. 
      Frequency-specific (2-31.5 kHz) auditory brainstem responses were used to obtain 
      the hearing thresholds before and 2, 5 and 15 days after instillation. 
      Results--PaExoA penetrated from the middle ear into the cochlea, causing 
      initially mixed hearing loss, followed by persistent sensorineural hearing loss. 
      This impairment was blocked by BDNF at 6, 8 and 10 kHz on Day 2 and at 8 kHz on 
      Day 5. L-NAME given in combination with BDNF did not show any additional 
      protective effect. There were no significant differences in the thickness of the 
      round window membrane between control ears and those in each instillation group. 
      Conclusion--Our results suggest that BDNF may protect against cochlear damage 
      caused by PaExoA in the middle turns of the ear.
FAU - Maeta, Manabu
AU  - Maeta M
AD  - a Department of Otorhinolaryngology & Head and Neck Surgery, University Hospital 
      Uppsala, Uppsala, Sweden.
AD  - b Department of Otolaryngology, Head and Neck Surgery, Okayama UNiversity 
      Graduate School of Medicine and Dentistry, Okayama, Japan.
FAU - Anniko, Matti
AU  - Anniko M
AD  - a Department of Otorhinolaryngology & Head and Neck Surgery, University Hospital 
      Uppsala, Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
OTO - NOTNLM
OT  - Auditory Brainstem Response
OT  - Brain-derived Neurotrophic Factor
OT  - NG-nitro-L-arginine Methyl Ester
OT  - Pseudomonas aeruginosa Exotoxin A
OT  - Round Window Membranee
OT  - Sensorineural Hearing Loss
EDAT- 2003/01/01 00:00
MHDA- 2003/01/01 00:01
CRDT- 2017/04/21 06:00
PHST- 2017/04/21 06:00 [entrez]
PHST- 2003/01/01 00:00 [pubmed]
PHST- 2003/01/01 00:01 [medline]
AID - 10.1080/0036554021000028090 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2003 Jan 1;123(1):14-19. doi: 10.1080/0036554021000028090.