PMID- 28425496
OWN - NLM
STAT- MEDLINE
DCOM- 20180424
LR  - 20181113
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 42
IP  - 10
DP  - 2017 Sep
TI  - 3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel 
      Monkeys in a Serotonin 2A Receptor-Dependent Manner.
PG  - 1962-1971
LID - 10.1038/npp.2017.80 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) increases sociality in humans and 
      animals. Release of serotonin (5-HT) is thought to have an important role in the 
      increase in social behaviors, but the mechanisms underlying these effects are 
      poorly understood. Despite the advantages of nonhuman primate models, no studies 
      have examined the mechanisms of the social effects of MDMA in nonhuman primates. 
      The behavior and vocalizations of four group-housed squirrel monkeys were 
      examined following administration of MDMA, its enantiomers, and methamphetamine. 
      5-HT receptor antagonists and agonists were given as drug pretreatments. Data 
      were analyzed using linear mixed-effects models. MDMA and its enantiomers 
      increased affiliative social behaviors and vocalizations, whereas methamphetamine 
      had only modest effects on affiliative behaviors. Pretreatment with a 5-HT(2A) 
      receptor antagonist and a 5-HT(2C) receptor agonist attenuated the MDMA-induced 
      increase in social behaviors, while a 5-HT(1A) receptor antagonist did not alter 
      affiliative vocalizations and increased MDMA-induced social contact. Nonhuman 
      primates show MDMA-specific increases in affiliative social behaviors following 
      MDMA administration, in concordance with human and rodent studies. MDMA-induced 
      increases in social behaviors are 5-HT(2A), but not 5-HT(1A), receptor dependent. 
      Understanding the neurochemical mechanisms mediating the prosocial effects of 
      MDMA could help in the development of novel therapeutics with the unique social 
      effects of MDMA but fewer of its limitations.
FAU - Pitts, Elizabeth G
AU  - Pitts EG
AD  - Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
FAU - Minerva, Adelaide R
AU  - Minerva AR
AUID- ORCID: 0000-0002-0038-8493
AD  - Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
FAU - Chandler, Erika B
AU  - Chandler EB
AD  - Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
FAU - Kohn, Jordan N
AU  - Kohn JN
AD  - Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
FAU - Logun, Meghan T
AU  - Logun MT
AD  - Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
FAU - Sulima, Agnieszka
AU  - Sulima A
AD  - Drug Design and Synthesis Section, Molecular Targets and Medications Discovery 
      Branch, National Institute on Drug Abuse and the National Institute on Alcohol 
      Abuse and Alcoholism, Bethesda, MD, USA.
FAU - Rice, Kenner C
AU  - Rice KC
AD  - Drug Design and Synthesis Section, Molecular Targets and Medications Discovery 
      Branch, National Institute on Drug Abuse and the National Institute on Alcohol 
      Abuse and Alcoholism, Bethesda, MD, USA.
FAU - Howell, Leonard L
AU  - Howell LL
AD  - Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, 
      USA.
LA  - eng
GR  - K05 DA031246/DA/NIDA NIH HHS/United States
GR  - P51 OD011132/OD/NIH HHS/United States
GR  - R01 DA012514/DA/NIDA NIH HHS/United States
GR  - T32 NS096050/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20170420
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Serotonin Agents)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Linear Models
MH  - Male
MH  - Methamphetamine/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Psychotropic Drugs/*pharmacology
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - Receptor, Serotonin, 5-HT2A/*metabolism
MH  - Saimiri
MH  - Serotonin Agents/pharmacology
MH  - *Social Behavior
MH  - Vocalization, Animal/drug effects/physiology
PMC - PMC5561347
EDAT- 2017/04/21 06:00
MHDA- 2018/04/25 06:00
PMCR- 2018/09/01
CRDT- 2017/04/21 06:00
PHST- 2017/01/02 00:00 [received]
PHST- 2017/04/05 00:00 [revised]
PHST- 2017/04/16 00:00 [accepted]
PHST- 2017/04/21 06:00 [pubmed]
PHST- 2018/04/25 06:00 [medline]
PHST- 2017/04/21 06:00 [entrez]
PHST- 2018/09/01 00:00 [pmc-release]
AID - npp201780 [pii]
AID - 10.1038/npp.2017.80 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2017 Sep;42(10):1962-1971. doi: 10.1038/npp.2017.80. 
      Epub 2017 Apr 20.