PMID- 28426339
OWN - NLM
STAT- MEDLINE
DCOM- 20170912
LR  - 20220318
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 123
IP  - 4
DP  - 2017 Oct
TI  - Fasting levels of insulin and amylin after acute pancreatitis are associated with 
      pro-inflammatory cytokines.
PG  - 238-248
LID - 10.1080/13813455.2017.1308382 [doi]
AB  - BACKGROUND: The prevalence of metabolic diseases continues to rise worldwide, 
      with a growing recognition of metabolic dysregulation after acute inflammatory 
      diseases such as acute pancreatitis (AP). Adipokines and cytokines play an 
      important role in metabolism and the course of AP, but there is a paucity of 
      research investigating their relationship with pancreatic hormones after AP. This 
      study aimed to explore associations between pancreatic hormones and adipokines as 
      well as cytokines to provide insights into the pathophysiology of altered 
      pancreatic hormone secretion following AP [corrected]. METHODS: A total of 83 
      patients previously diagnosed with AP and no prior diabetes or pre-diabetes were 
      recruited into this cross-sectional follow up study. Fasting venous blood samples 
      were collected to analyse a panel of pancreatic hormones and derivatives (amylin, 
      C-peptide, glucagon, insulin, pancreatic polypeptide, somatostatin), adipokines 
      (adiponectin, leptin, retinol binding protein-4, and resistin), and cytokines 
      (interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumour 
      necrosis factor-alpha (TNF-alpha)). Linear regression analyses were used, and potential 
      confounders were adjusted for in multivariate analyses. RESULTS: Insulin was 
      significantly associated with IL-6 in both unadjusted and adjusted models 
      (p = .029 and p = .040, respectively). Amylin was significantly associated with 
      MCP-1 in the unadjusted model (p = .046), and TNF-alpha in unadjusted and adjusted 
      models (p = .025 and p = .027, respectively). CONCLUSIONS: Insulin and amylin 
      have a strong positive association with pro-inflammatory cytokines in patients 
      following an episode of AP. These associations have possible relevance in the 
      development of diabetes associated with diseases of the exocrine pancreas, 
      providing the opportunity to develop novel treatment paradigms.
FAU - Gillies, Nicola A
AU  - Gillies NA
AD  - a Department of Surgery , University of Auckland , Auckland , New Zealand.
FAU - Pendharkar, Sayali A
AU  - Pendharkar SA
AD  - a Department of Surgery , University of Auckland , Auckland , New Zealand.
FAU - Singh, Ruma G
AU  - Singh RG
AD  - a Department of Surgery , University of Auckland , Auckland , New Zealand.
FAU - Windsor, John A
AU  - Windsor JA
AD  - a Department of Surgery , University of Auckland , Auckland , New Zealand.
FAU - Bhatia, Madhav
AU  - Bhatia M
AD  - b Department of Pathology , Otago University , Christchurch , New Zealand.
FAU - Petrov, Maxim S
AU  - Petrov MS
AD  - a Department of Surgery , University of Auckland , Auckland , New Zealand.
LA  - eng
PT  - Journal Article
DEP - 20170420
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 0 (Leptin)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
EIN - Arch Physiol Biochem. 2017 Oct;123(4):i. PMID: 28557619
MH  - Acute Disease
MH  - Adiponectin/blood
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/blood
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Cytokines/*blood
MH  - Fasting/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Insulin/*blood
MH  - Interleukin-6/blood
MH  - Islet Amyloid Polypeptide/*blood
MH  - Leptin/blood
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/*blood/pathology
MH  - Resistin/blood
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Insulin
OT  - acute pancreatitis
OT  - amylin
OT  - cytokines
OT  - low-grade inflammation
OT  - post-pancreatitis diabetes
EDAT- 2017/04/21 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/04/21 06:00
PHST- 2017/04/21 06:00 [pubmed]
PHST- 2017/09/13 06:00 [medline]
PHST- 2017/04/21 06:00 [entrez]
AID - 10.1080/13813455.2017.1308382 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2017 Oct;123(4):238-248. doi: 
      10.1080/13813455.2017.1308382. Epub 2017 Apr 20.