PMID- 28427482
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20181113
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Print)
IS  - 0954-5794 (Linking)
VI  - 30
IP  - 1
DP  - 2018 Feb
TI  - A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts 
      with hostile parenting to predict error-related brain activity and thereby risk 
      for internalizing disorders in children.
PG  - 125-141
LID - 10.1017/S0954579417000517 [doi]
AB  - The error-related negativity (ERN) is a negative deflection in the event-related 
      potential occurring when individuals make mistakes, and is increased in children 
      with internalizing psychopathology. We recently found that harsh parenting 
      predicts a larger ERN in children, and recent work has suggested that variation 
      in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of 
      early life adversity. Parents and children completed measures of parenting when 
      children were 3 years old (N = 201); 3 years later, the ERN was measured and 
      diagnostic interviews as well as dimensional symptom measures were completed. We 
      found that harsh parenting predicted an increased ERN only among children with a 
      methionine allele of the BDNF genotype, and evidence of moderated mediation: the 
      ERN mediated the relationship between parenting and internalizing diagnoses and 
      dimensional symptoms only if children had a methionine allele. We tested this 
      model with externalizing disorders, and found that harsh parenting predicted 
      externalizing outcomes, but the ERN did not mediate this association. These 
      findings suggest that harsh parenting predicts both externalizing and 
      internalizing outcomes in children; however, this occurs through different 
      pathways that uniquely implicate error-related brain activity in the development 
      of internalizing disorders.
FAU - Meyer, Alexandria
AU  - Meyer A
AD  - Florida State University.
FAU - Hajcak, Greg
AU  - Hajcak G
AD  - Florida State University.
FAU - Hayden, Elizabeth
AU  - Hayden E
AD  - Florida State University.
FAU - Sheikh, Haroon I
AU  - Sheikh HI
AD  - Florida State University.
FAU - Singh, Shiva M
AU  - Singh SM
AD  - Florida State University.
FAU - Klein, Daniel N
AU  - Klein DN
AD  - Florida State University.
LA  - eng
GR  - R01 MH069942/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20170421
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Defense Mechanisms
MH  - Electroencephalography
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - *Gene-Environment Interaction
MH  - *Hostility
MH  - Humans
MH  - Male
MH  - Parenting/*psychology
MH  - Polymorphism, Genetic
PMC - PMC5752624
MID - NIHMS930832
EDAT- 2017/04/22 06:00
MHDA- 2018/09/27 06:00
PMCR- 2018/05/01
CRDT- 2017/04/22 06:00
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2017/04/22 06:00 [entrez]
PHST- 2018/05/01 00:00 [pmc-release]
AID - S0954579417000517 [pii]
AID - 10.1017/S0954579417000517 [doi]
PST - ppublish
SO  - Dev Psychopathol. 2018 Feb;30(1):125-141. doi: 10.1017/S0954579417000517. Epub 
      2017 Apr 21.