PMID- 28427565
OWN - NLM
STAT- MEDLINE
DCOM- 20171030
LR  - 20180816
IS  - 1876-1623 (Print)
IS  - 1876-1623 (Linking)
VI  - 108
DP  - 2017
TI  - Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A 
      Computational Approach.
PG  - 85-103
LID - S1876-1623(17)30006-8 [pii]
LID - 10.1016/bs.apcsb.2017.01.006 [doi]
AB  - Mental disorders or mood disorders are prevalent globally irrespective of region, 
      race, and ethnic groups. Of the types of mood disorders, major depressive 
      disorder (MDD) and bipolar disorder (BPD) are the most prevalent forms of 
      psychiatric condition. A number of preclinical studies emphasize the essential 
      role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of mood 
      disorders. Additionally, BDNF is the most common growth factor in the central 
      nervous system along with their essential role during the neural development and 
      the synaptic elasticity. A malfunctioning of this protein is associated with many 
      types of mood disorders. The variant methionine replaces valine at 66th position 
      is strongly related to BPD, and an individual with a homozygous condition of this 
      allele is at a greater risk of developing MDD. There are very sparse reports 
      suggesting the structural changes of the protein occurring upon the mutation. 
      Consequently, in this study, we applied a computational pipeline to understand 
      the effects caused by the mutation on the protein's structure and function. With 
      the use of in silico tools and computational macroscopic methods, we identified a 
      decrease in the alpha-helix nature, and an overall increase in the random coils 
      that could have probably resulted in deformation of the protein.
CI  - (c) 2017 Elsevier Inc. All rights reserved.
FAU - Sneha, P
AU  - Sneha P
AD  - School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
FAU - Thirumal Kumar, D
AU  - Thirumal Kumar D
AD  - School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
FAU - Saini, Sugandhi
AU  - Saini S
AD  - School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
FAU - Kajal, Kreeti
AU  - Kajal K
AD  - School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
FAU - Magesh, R
AU  - Magesh R
AD  - Faculty of Research and Bio Medical Sciences, Sri Ramachandra University, 
      Chennai, Tamil Nadu, India.
FAU - Siva, R
AU  - Siva R
AD  - School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India. 
      Electronic address: siva.ramamoorthy@gmail.com.
FAU - George Priya Doss, C
AU  - George Priya Doss C
AD  - School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India. 
      Electronic address: georgecp77@yahoo.co.in.
LA  - eng
PT  - Journal Article
DEP - 20170309
PL  - Netherlands
TA  - Adv Protein Chem Struct Biol
JT  - Advances in protein chemistry and structural biology
JID - 101497281
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics/metabolism
MH  - Conserved Sequence
MH  - Humans
MH  - Methionine/genetics
MH  - Molecular Dynamics Simulation
MH  - Mood Disorders/*genetics
MH  - *Point Mutation
MH  - Protein Interaction Maps
MH  - Protein Structure, Secondary
MH  - Valine/genetics
OTO - NOTNLM
OT  - BDNF
OT  - In silico tools
OT  - Molecular dynamics
OT  - Mood disorder
OT  - V66M
EDAT- 2017/04/22 06:00
MHDA- 2017/10/31 06:00
CRDT- 2017/04/22 06:00
PHST- 2017/04/22 06:00 [entrez]
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2017/10/31 06:00 [medline]
AID - S1876-1623(17)30006-8 [pii]
AID - 10.1016/bs.apcsb.2017.01.006 [doi]
PST - ppublish
SO  - Adv Protein Chem Struct Biol. 2017;108:85-103. doi: 10.1016/bs.apcsb.2017.01.006. 
      Epub 2017 Mar 9.