PMID- 28427824
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20180905
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 117
IP  - 3
DP  - 2018 Mar
TI  - Association between monocyte chemoattractant protein-1 -2518 A/G gene 
      polymorphism and the outcome of the nonsurgical periodontal treatment.
PG  - 191-196
LID - S0929-6646(17)30021-9 [pii]
LID - 10.1016/j.jfma.2017.03.013 [doi]
AB  - BACKGROUND/PURPOSE: Elevated monocyte chemoattractant protein-1 (MCP-1) is 
      related to severe periodontal destruction. Furthermore, MCP-1 -2518 A/G gene 
      polymorphism affects MCP-1 after inflammatory stimuli. This study analyzed the 
      association between MCP-1 -2518 gene polymorphism and the outcome of nonsurgical 
      periodontal treatment. METHODS: Forty periodontal patients were recruited and 
      MCP-1 -2518 A/G gene polymorphisms were analyzed using polymerase chain 
      reaction-restriction fragment length polymorphism assay. The clinical periodontal 
      parameters, including probing depth (PD), clinical attachment level (CAL), 
      gingival index (GI), bleeding index (BI) and plaque index (PI), were recorded 
      before and six weeks after nonsurgical periodontal therapy. Patients were divided 
      into chronic periodontitis (CP) or aggressive periodontitis (AP). Multiple linear 
      regression analysis was performed to investigate certain predictors of the 
      therapy outcome. RESULTS: The frequency of MCP-1 -2518 genotype-positive 
      (carrying allele G) was 42.5%. Poor treatment outcome in PD, GI and BI 
      improvement could be predicted with MCP-1 -2518 A/G genotype and aggressive 
      periodontitis status as the predictor variables. In contrast, MCP-1 -2518 A/A 
      genotype and aggressive periodontitis status could predict better treatment 
      response in PD and BI improvement. However, MCP-1 -2518 genotype did not affect 
      the treatment outcome in patients with chronic periodontitis. CONCLUSION: MCP-1 
      -2518 A/G genotype might be useful in predicting less favorable nonsurgical 
      treatment outcome in patients with aggressive periodontitis. However, MCP-1 -2518 
      gene polymorphism may not play a role in patients with chronic periodontitis. 
      This study suggests that MCP-1 -2518 genotype may influence the outcome of 
      nonsurgical periodontal treatment in aggressive periodontitis patients.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Chang, Ching-Wen
AU  - Chang CW
AD  - Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Lin, Hsiu-Hui
AU  - Lin HH
AD  - Department of Dentistry, National Yang-Ming University, Taipei, Taiwan.
FAU - Wu, Shih-Yun
AU  - Wu SY
AD  - Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Dentistry, National Yang-Ming University, Taipei, Taiwan.
FAU - Wu, Ching-Yi
AU  - Wu CY
AD  - Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan.
FAU - Lai, Yu-Lin
AU  - Lai YL
AD  - Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Dentistry, National Yang-Ming University, Taipei, Taiwan.
FAU - Hung, Shan-Ling
AU  - Hung SL
AD  - Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Dentistry, National Yang-Ming University, Taipei, Taiwan; Institute 
      of Oral Biology, National Yang-Ming University, Taipei, Taiwan. Electronic 
      address: slhung@ym.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20170417
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aggressive Periodontitis/*genetics/therapy
MH  - Chemokine CCL2/analysis/*genetics
MH  - Chronic Periodontitis/*genetics/therapy
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
OTO - NOTNLM
OT  - Genetic polymorphism
OT  - Monocyte chemoattractant protein-1
OT  - Nonsurgical periodontal treatment
OT  - Periodontitis
EDAT- 2017/04/22 06:00
MHDA- 2018/09/06 06:00
CRDT- 2017/04/22 06:00
PHST- 2017/01/13 00:00 [received]
PHST- 2017/03/21 00:00 [revised]
PHST- 2017/03/29 00:00 [accepted]
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2017/04/22 06:00 [entrez]
AID - S0929-6646(17)30021-9 [pii]
AID - 10.1016/j.jfma.2017.03.013 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2018 Mar;117(3):191-196. doi: 10.1016/j.jfma.2017.03.013. 
      Epub 2017 Apr 17.